Mice with a recessive gene which reduces the number of ganglion cells of the distal colon and rectum and produces megacolon, imitating Hirschsprung disease, are discussed as a model for integrative control of the large intestinal smooth musculature by the enteric division of the autonomic nervous system (ie, the brain-in-the-gut). Investigative approaches, such as propulsion of artificial pellets in preparations of whole colon in organ baths in vitro and innovative approaches capitalizing on neurogenetic technologies (eg, optogenetics), are considered in view of potential application in the development of novel therapeutic mechanisms to selectively evoke and control gastrointestinal motility patterns, such as the small intestinal digestive motility pattern, interdigestive pattern, and reversed direction of powerful propulsive motility during emesis. This minireview relates to the paper titled: “Motor patterns in the proximal and distal mouse colon which underlie formation and propulsion of feces,” appearing in this issue of Neurogastroenterology and Motility.

中文翻译：

---

小鼠大肠的运动行为：Minireview

具有隐性基因的小鼠减少远端结肠和直肠的神经节细胞数量并产生巨结肠，模仿先天性巨结肠，被讨论为通过自主神经系统的肠道分裂综合控制大肠平滑肌组织的模型。即肠道中的大脑）。研究方法，例如在体外器官浴中制备全结肠时推进人造颗粒考虑到在开发新的治疗机制以选择性诱发和控制胃肠道运动模式（例如小肠消化运动模式、消化间模式和逆转呕吐时强大的推进动力的方向。这篇小评论与本期《神经胃肠病学和运动学》上发表的论文有关：“小鼠近端和远端结肠的运动模式是粪便形成和推进的基础”。