A putative anti-inflammatory role for TRPM8 in irritable bowel syndrome—An exploratory study,Neurogastroenterology & Motility

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A putative anti-inflammatory role for TRPM8 in irritable bowel syndrome—An exploratory study
Neurogastroenterology & Motility ( IF 3.5 ) Pub Date : 2021-06-19 , DOI: 10.1111/nmo.14170
Madusha Peiris ₁ , Zsa Zsa R M Weerts ₂ , Rubina Aktar ₁ , Ad A M Masclee ₂ , Ashley Blackshaw ₁ , Daniel Keszthelyi ₂

Affiliation

Chronic and recurring pain is a characteristic symptom in irritable bowel syndrome (IBS). Altered signaling between immune cells and sensory neurons within the gut may promote generation of pain symptoms. As transient receptor potential melastatin 8 (TRPM8) agonists, such as L-menthol in peppermint oil, have shown to attenuate IBS pain symptoms, we began investigating potential molecular mechanisms.

中文翻译：

TRPM8 在肠易激综合征中的推定抗炎作用——一项探索性研究

慢性和反复发作的疼痛是肠易激综合征 (IBS) 的特征性症状。肠道内免疫细胞和感觉神经元之间的信号改变可能会促进疼痛症状的产生。由于瞬时受体电位黑色素 8 (TRPM8) 激动剂，如薄荷油中的 L-薄荷醇，已显示可减轻 IBS 疼痛症状，因此我们开始研究潜在的分子机制。

更新日期：2021-06-19

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