Accurate and complete replication of the genome is essential not only for genome stability but also for cell viability. However, cells face constant threats to the replication process, such as spontaneous DNA modifications and DNA lesions from endogenous and external sources. Any obstacle that slows down replication forks or perturbs replication dynamics is generally considered to be a form of replication stress, and the past decade has seen numerous advances in our understanding of how cells respond to and resolve such challenges. Furthermore, recent studies have also uncovered links between defects in replication stress responses and genome instability or various diseases, such as cancer. Because replication stress takes place in the context of chromatin, histone dynamics play key roles in modulating fork progression and replication stress responses. Here, we summarize the current understanding of histone dynamics in replication stress, highlighting recent advances in the characterization of fork-protective mechanisms.

中文翻译：

---

DNA 复制应激期间的组蛋白动力学


基因组的准确和完整复制不仅对于基因组稳定性而且对于细胞活力都至关重要。然而，细胞的复制过程面临着持续的威胁，例如自发的 DNA 修饰和来自内源性和外源性的 DNA 损伤。任何减缓复制叉或扰乱复制动态的障碍通常被认为是复制压力的一种形式，在过去的十年里，我们在理解细胞如何应对和解决此类挑战方面取得了许多进展。此外，最近的研究还发现了复制应激反应缺陷与基因组不稳定性或癌症等各种疾病之间的联系。由于复制应激发生在染色质环境中，因此组蛋白动力学在调节分叉进展和复制应激反应中发挥着关键作用。在这里，我们总结了目前对复制应激中组蛋白动力学的理解，重点介绍了叉保护机制表征的最新进展。