The entry of blood-borne molecules into the brain is restricted by the blood–brain barrier (BBB). Various physical, transport and immune properties tightly regulate molecule movement between the blood and the brain to maintain brain homeostasis. A recent study utilizing a pan-endothelial, constitutive Tie2-Cre showed that paracellular passage of blood proteins into the brain is governed by endocytic and cell signaling protein low-density lipoprotein receptor–related protein 1 (LRP1). Taking advantage of conditional Slco1c1-CreERT2 specific to CNS endothelial cells and choroid plexus epithelial cells we now supplement previous results and show that brain endothelial Lrp1 ablation results in protease-mediated tight junction degradation, P-glycoprotein (P-gp) reduction and a loss of BBB integrity.

中文翻译：

---

脑内皮 LRP1 维持血脑屏障完整性

血源性分子进入大脑受到血脑屏障 (BBB) 的限制。各种物理、运输和免疫特性严格调节血液和大脑之间的分子运动，以维持大脑稳态。最近一项利用泛内皮、组成型 Tie2-Cre 的研究表明，血液蛋白进入大脑的细胞旁通道受内吞和细胞信号蛋白低密度脂蛋白受体相关蛋白 1 (LRP1) 控制。利用特定于 CNS 内皮细胞和脉络丛上皮细胞的条件性 Slco1c1-CreERT2，我们现在补充先前的结果，并表明脑内皮 Lrp1 消融导致蛋白酶介导的紧密连接降解、P-糖蛋白 (P-gp) 减少和损失BBB 的完整性。