Enhanced Near-Infrared Photocatalytic Eradication of MRSA Biofilms and Osseointegration Using Oxide Perovskite-Based P–N Heterojunction,Advanced Science

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Enhanced Near-Infrared Photocatalytic Eradication of MRSA Biofilms and Osseointegration Using Oxide Perovskite-Based P–N Heterojunction
Advanced Science ( IF 14.3 ) Pub Date : 2021-06-19 , DOI: 10.1002/advs.202002211
Congyang Mao _{1,

2} , Weidong Zhu ₃ , Yiming Xiang _{1,

2} , Yizhou Zhu _{1,

2} , Jie Shen _{1,

2} , Xiangmei Liu ₃ , Shuilin Wu ₄ , Kenneth M C Cheung _{1,

2} , Kelvin Wai Kwok Yeung _{1,

2}

Affiliation

Methicillin-resistant Staphylococcus aureus (MRSA) biofilm infections after orthopedic implant increase the risk of failure and potentially cause amputation of limbs or life-threatening sepsis in severe cases. Additionally, satisfactory bone-implant integration is another important indicator of an ideal implant. Here, an antibiotic-free antibacterial nanofilm based on oxide perovskite-type calcium titanate (CTO)/fibrous red phosphorus (RP) on titanium implant surface (Ti-CTO/RP) in which the P–N heterojunction and internal electric field are established at the heterointerface, is designed. Near-infrared light-excited electron–hole pairs are effectively separated and transferred through the synergism of the internal electric field and band offset, which strongly boosts the photocatalytic eradication of MRSA biofilms by reactive oxygen species with an efficacy of 99.42% ± 0.22% in vivo. Additionally, the charge transfer endows the heterostructure with hyperthermia to assist biofilm eradication. Furthermore, CTO/RP nanofilm provides a superior biocompatible and osteoconductive platform that enables the proliferation and osteogenic differentiation of mesenchymal stem cells, thus contributing to the subsequent implant-to-bone osseointegration after eradicating MRSA biofilms.

中文翻译：

使用基于氧化物钙钛矿的 P-N 异质结增强近红外光催化消除 MRSA 生物膜和骨整合

骨科植入后耐甲氧西林金黄色葡萄球菌(MRSA) 生物膜感染会增加失败的风险，严重时可能导致截肢或危及生命的败血症。此外，令人满意的骨-种植体整合是理想种植体的另一个重要指标。这里，基于钛种植体表面氧化物钙钛矿型钛酸钙（CTO）/纤维红磷（RP）（Ti-CTO/RP）的无抗生素抗菌纳米膜，其中建立了P-N异质结和内部电场在异质接口处，被设计。近红外光激发的电子空穴对通过内部电场和能带偏移的协同作用有效分离和转移，有力地促进了活性氧对MRSA生物膜的光催化消灭，效率达到99.42%±0.22%体内。此外，电荷转移赋予异质结构高温，以帮助根除生物膜。此外，CTO/RP纳米膜提供了卓越的生物相容性和骨传导平台，使间充质干细胞能够增殖和成骨分化，从而有助于根除MRSA生物膜后随后的种植体到骨的骨整合。

更新日期：2021-08-04

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