Abstract

In this study, some novel pyridopyrimidines were synthesized via one-pot three-component reaction of 6-amino-N,N-dimethyluracil, 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile and aromatic aldehydes in DMF under reflux conditions in the presence of 1-carboxymethyl-2,3-dimethylimidazolium iodide {[cmdmim]I} as a catalyst. The present procedure shows several advantages such as short reaction times, high yields, simple work-up and use of non-expensive and nontoxic materials. All products were characterized by spectroscopic (FT-IR, ¹H and ¹³C NMR) analyses.

中文翻译：

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以 1-Carboxymethyl-2,3-Dimethylimidazolium Iodide {[cmdmim]I} 作为可回收催化剂，聚合一锅法合成新型吡咯-吡啶并嘧啶杂化物

摘要

本研究通过6-氨基-N,N-二甲基尿嘧啶、3-(1-甲基-1 H-吡咯-2-基)-3-氧代丙腈和芳烃的一锅三组分反应合成了一些新型吡啶并嘧啶。在 1-羧甲基-2,3-二甲基咪唑鎓碘化物 {[cmdmim]I} 作为催化剂存在的情况下，在回流条件下，DMF 中的醛。本方法显示出几个优点，例如反应时间短、产率高、后处理简单以及使用非昂贵和无毒的材料。所有产品均通过光谱（FT-IR、¹ H 和¹³ C NMR）分析进行表征。