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Cannabis chemistry, post-harvest processing methods and secondary metabolite profiling: A review
Industrial Crops and Products ( IF 5.6 ) Pub Date : 2021-06-17 , DOI: 10.1016/j.indcrop.2021.113743
Philip Wiredu Addo , Vincent Desaulniers Brousseau , Victorio Morello , Sarah MacPherson , Maxime Paris , Mark Lefsrud

Differences in cannabis (Cannabis sativa L.) plant chemistry between strains are influenced by genetics, plant growth and development, in addition to environmental conditions such as abiotic and biotic stress. Resulting secondary metabolite profiles are further altered post-harvest by drying and extraction, all of which present sizable challenges to industrial scale producers of pharmaceutical grade products in Canada and elsewhere. Consistent quantity and quality of cannabis extracts, demonstrated by preferred cannabinoid ratios and other secondary metabolites present are important, particularly as the list of therapeutic uses for medical cannabis is expanding. As more countries contemplate the legalization and licensure of medical cannabis, the number of cannabis extraction and testing laboratories is increasing to keep up with demand. However, it is not always known what standards are adhered to, resulting in numerous non-validated methods. In this review, a summary of cannabis chemistry and biosynthesis of secondary compounds is provided, and post-harvest processing practices occurring along the cannabis product value chain that might affect cannabis phytochemistry, potency and volatility are presented. An emphasis is placed on improved drying and extraction methods for plant material suitable for the cannabis industry. Finally, new approaches to secondary metabolite profiling for cannabis products are compared.



中文翻译:

大麻化学、收获后加工方法和次级代谢物分析:综述

大麻的差异(Cannabis sativaL.) 除了诸如非生物和生物胁迫等环境条件之外,菌株之间的植物化学还受遗传、植物生长和发育的影响。收获后通过干燥和提取进一步改变了产生的次级代谢物谱,所有这些都给加拿大和其他地方的医药级产品的工业规模生产商带来了相当大的挑战。大麻提取物的数量和质量一致,由优选的大麻素比例和其他次级代谢产物证明是很重要的,特别是在医用大麻的治疗用途清单正在扩大的情况下。随着越来越多的国家考虑医用大麻的合法化和许可,大麻提取和检测实验室的数量正在增加以满足需求。然而,并不总是知道遵守哪些标准,从而导致许多未经验证的方法。在本次审查中,提供了大麻化学和次级化合物生物合成的摘要,并介绍了可能影响大麻植物化学、效力和挥发性的大麻产品价值链中发生的收获后加工做法。重点放在适用于大麻产业的植物材料的改进干燥和提取方法上。最后,比较了大麻产品次级代谢物分析的新方法。介绍了大麻产品价值链中可能影响大麻植物化学、效力和挥发性的收获后加工做法。重点放在适用于大麻产业的植物材料的改进干燥和提取方法上。最后,比较了大麻产品次级代谢物分析的新方法。介绍了大麻产品价值链中可能影响大麻植物化学、效力和挥发性的收获后加工做法。重点放在适用于大麻产业的植物材料的改进干燥和提取方法上。最后,比较了大麻产品次级代谢物分析的新方法。

更新日期:2021-06-18
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