Continuous Pilot-Scale Wet-Spinning of Biocompatible Chitin/Chitosan Multifilaments from an Aqueous KOH/Urea Solution,Macromolecular Rapid Communications

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Continuous Pilot-Scale Wet-Spinning of Biocompatible Chitin/Chitosan Multifilaments from an Aqueous KOH/Urea Solution
Macromolecular Rapid Communications ( IF 4.2 ) Pub Date : 2021-06-17 , DOI: 10.1002/marc.202100252
Junchao Huang ₁ , Yi Zhong ₁ , Xi Zhang ₁ , Huan Xu ₁ , Caizhen Zhu ₂ , Jie Cai _{1,

3}

Affiliation

Chitin is a promising natural polymer with great potential as a biomedical, hygiene, absorbent, and food-packing material. Producing chitin multifilament and assembling them into textiles is an efficient way of preparing these materials, with wet-spinning a major method used to produce man-made fibers. Unfortunately, dissolving chitin, producing a stable and suitable chitin dope, and ensuring filament strength are the main obstacles to the production of chitin multifilament. Based on recent research into chitin dissolution, solution properties, and high-strength chitin-based materials, chitin multifilament wet-spinning is no longer only a hypothetical strategy. Here, a pilot-scale wet-spinning method is introduced that overcomes the abovementioned limitations. A stable chitin spinning dope is prepared by dissolution and aging in an aqueous KOH/urea solution. A chitin multifilament is prepared by wet-spinning using a pilot-scale wet-spinning apparatus and aqueous alcohol/salt coagulation. After deacetylation, the chitosan multifilament possesses a dense structure and low crystallinity, but excellent mechanical properties. The chitin/chitosan multifilaments exhibit excellent cytocompatibilities and have promising prospects in biomedical applications. The method developed in this work provides a new approach for the pilot-scale wet-spinning of chitin/chitosan multifilaments.

中文翻译：

来自 KOH/尿素水溶液的生物相容性几丁质/壳聚糖复丝的连续中试规模湿纺

甲壳素是一种很有前途的天然聚合物，具有作为生物医学、卫生、吸收剂和食品包装材料的巨大潜力。生产几丁质复丝并将它们组装成纺织品是制备这些材料的有效方法，湿纺是生产人造纤维的主要方法。不幸的是，溶解甲壳素、生产稳定合适的甲壳素原液以及保证长丝强度是甲壳素复丝生产的主要障碍。根据最近对几丁质溶解、溶液性质和高强度几丁质基材料的研究，几丁质复丝湿纺不再只是一种假设的策略。在这里，引入了一种克服上述限制的中试规模湿纺方法。通过在 KOH/尿素水溶液中溶解和老化制备稳定的几丁质纺丝原液。甲壳素复丝是通过使用中试规模的湿纺设备和含水酒精/盐凝结的湿纺制备的。脱乙酰后的壳聚糖复丝结构致密，结晶度低，但具有优异的机械性能。几丁质/壳聚糖复丝表现出优异的细胞相容性，在生物医学应用中具有广阔的前景。这项工作中开发的方法为几丁质/壳聚糖复丝的中试规模湿纺提供了一种新方法。壳聚糖复丝结构致密，结晶度低，但机械性能优良。几丁质/壳聚糖复丝表现出优异的细胞相容性，在生物医学应用中具有广阔的前景。这项工作中开发的方法为几丁质/壳聚糖复丝的中试规模湿纺提供了一种新方法。壳聚糖复丝结构致密，结晶度低，但机械性能优良。几丁质/壳聚糖复丝表现出优异的细胞相容性，在生物医学应用中具有广阔的前景。这项工作中开发的方法为几丁质/壳聚糖复丝的中试规模湿纺提供了一种新方法。

更新日期：2021-08-20

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