当前位置: X-MOL 学术Proc. Natl. Acad. Sci. U.S.A. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
High-resolution multicontrast tomography with an X-ray microarray anode-structured target source [Applied Physical Sciences]
Proceedings of the National Academy of Sciences of the United States of America ( IF 9.4 ) Pub Date : 2021-06-22 , DOI: 10.1073/pnas.2103126118
Guibin Zan 1 , Sheraz Gul 2 , Jin Zhang 1 , Wei Zhao 3 , Sylvia Lewis 2 , David J Vine 4 , Yijin Liu 5 , Piero Pianetta 1 , Wenbing Yun 2
Affiliation  

Multicontrast X-ray imaging with high resolution and sensitivity using Talbot–Lau interferometry (TLI) offers unique imaging capabilities that are important to a wide range of applications, including the study of morphological features with different physical properties in biological specimens. The conventional X-ray TLI approach relies on an absorption grating to create an array of micrometer-sized X-ray sources, posing numerous limitations, including technical challenges associated with grating fabrication for high-energy operations. We overcome these limitations by developing a TLI system with a microarray anode–structured target (MAAST) source. The MAAST features an array of precisely controlled microstructured metal inserts embedded in a diamond substrate. Using this TLI system, tomography of a Drum fish tooth with high resolution and tri-contrast (absorption, phase, and scattering) reveals useful complementary structural information that is inaccessible otherwise. The results highlight the exceptional capability of high-resolution multicontrast X-ray tomography empowered by the MAAST-based TLI method in biomedical applications.



中文翻译:

具有 X 射线微阵列阳极结构靶源的高分辨率多重对比断层扫描 [应用物理科学]

使用 Talbot-Lau 干涉测量法 (TLI) 具有高分辨率和灵敏度的多对比 X 射线成像提供了独特的成像能力,这对广泛的应用很重要,包括研究生物标本中具有不同物理特性的形态特征。传统的 X 射线 TLI 方法依赖于吸收光栅来创建微米尺寸的 X 射线源阵列,存在许多限制,包括与用于高能操作的光栅制造相关的技术挑战。我们通过开发具有微阵列阳极结构目标 (MAAST) 源的 TLI 系统来克服这些限制。MAAST 具有一系列精确控制的微结构金属嵌件,嵌入金刚石基材中。使用这个 TLI 系统,具有高分辨率和三对比(吸收、相位和散射)的鼓鱼牙齿的断层扫描揭示了有用的补充结构信息,否则无法获得。结果突出了基于 MAAST 的 TLI 方法在生物医学应用中赋予的高分辨率多对比 X 射线断层扫描的卓越能力。

更新日期:2021-06-18
down
wechat
bug