Stress-related disorders are extremely harmful and cause significant impacts on the individual and society. Despite the limited evidence regarding glucagon-like peptide-1 receptor (GLP-1R) and mental disorders, a few clinical and preclinical studies suggest that modulating this system could improve symptoms of stress-related disorders. This study aimed to investigate the effects of liraglutide, a GLP-1R agonist, on neurobehavioral phenotypes and brain oxidative status in adult zebrafish. Acute liraglutide promoted anxiolytic-like effects in the light/dark test, while chronic treatment blocked the impact of unpredictable chronic stress on behavioral and physiological parameters. Taken together, our study demonstrates that liraglutide is active on the zebrafish brain and may counteract some of the effects induced by stress. More studies are warranted to further elucidate the potential of GLP-1R agonists for the management of brain disorders.

与压力有关的疾病是极其有害的，并对个人和社会造成重大影响。尽管关于胰高血糖素样肽 1 受体 (GLP-1R) 和精神障碍的证据有限，但一些临床和临床前研究表明，调节该系统可以改善压力相关疾病的症状。本研究旨在研究 GLP-1R 激动剂利拉鲁肽对成年斑马鱼神经行为表型和脑氧化状态的影响。急性利拉鲁肽在光/暗测试中促进抗焦虑样作用，而慢性治疗阻止了不可预测的慢性压力对行为和生理参数的影响。总之，我们的研究表明，利拉鲁肽对斑马鱼大脑有活性，并且可能抵消压力引起的一些影响。