Coronavirus disease 2019 (COVID-19) continues to have a devastating effect on a global scale. COVID-19 variants continue to arise and counteract vaccination efficacy. As such, preventative health measures, such as social distancing and stay at home mandates, will continue for the foreseeable future. Evidence on those at greatest risk for poor outcomes if infected with COVID-19 has rapidly come to light. It has become clear that those with unhealthy lifestyle characteristics, chronic disease risk factors and/or a confirmed diagnosis of one or more chronic conditions are at greatest risk for hospitalization, intensive care unit admission, mechanical ventilation, and death if infected with COVID-19. The cytokine storm is a phenomenon that has been posited as a pathophysiologic response to COVID-19 infection that leads to poor outcomes. The current graphical review illustrates the association between unhealthy lifestyle characteristics and increased vulnerability to the cytokine storm as well as the physiologic mechanisms healthy living behaviors elicit and decrease risk for the cytokine storm. Through this graphical review, we will demonstrate unhealthy lifestyle characteristics, chronic disease risk factors and diagnoses, and COVID-19 outcomes are intricately linked, creating a new global syndemic. It is also clear that a primary way to uncouple this syndemic is through increasing healthy living behaviors, as illustrated in this graphical review. Moving forward, healthy living medicine should be practiced with renewed vigor to improve human resiliency to health threats posed by both chronic disease and viral infections.

2019 年冠状病毒病 (COVID-19) 继续在全球范围内产生破坏性影响。COVID-19 变体继续出现并抵消了疫苗接种的功效。因此，在可预见的未来，诸如保持社交距离和居家令等预防性健康措施将继续存在。如果感染了 COVID-19，那些最有可能导致不良结果的人的证据迅速曝光。很明显，那些具有不健康生活方式特征、慢性病风险因素和/或确诊为一种或多种慢性病的人，如果感染 COVID-19，住院、重症监护病房、机械通气和死亡的风险最大. 细胞因子风暴是一种现象，被认为是对 COVID-19 感染的病理生理反应，会导致不良结果。当前的图形审查说明了不健康的生活方式特征与细胞因子风暴的易感性增加之间的关联，以及健康生活行为引发和降低细胞因子风暴风险的生理机制。通过这个图形审查，我们将展示不健康的生活方式特征、慢性病风险因素和诊断，以及 COVID-19 结果之间错综复杂的联系，从而创造了一种新的全球流行病。同样清楚的是，解除这种综合症的主要方法是通过增加健康的生活行为，如本图形审查所示。展望未来，应该以新的活力实践健康的生活医学，以提高人类对慢性病和病毒感染所带来的健康威胁的恢复能力。