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Gold nanoparticles and cancer: Detection, diagnosis and therapy
Seminars in Cancer Biology ( IF 12.1 ) Pub Date : 2021-06-18 , DOI: 10.1016/j.semcancer.2021.06.017
Serenella Medici 1 , Massimiliano Peana 1 , Donatella Coradduzza 2 , Maria Antonietta Zoroddu 1
Affiliation  

Gold nanoparticles (AuNPS) represent one of the most studied classes of nanomaterials for biomedical applications, especially in the field of cancer research. In fact, due to their unique properties and high versatility, they can be exploited under all aspects connected to cancer management, from early detection to diagnosis and treatment. AuNPs have thus been tested with amazing results as biosensors, contrast agents, therapeutics. Their importance as potent theranostics is undoubted, but the translation to clinical practice has been hampered by a series of aspects, such as the unclear toxicity in humans and the lack of thorough studies on reliable animal models. Still, their potential action is so appealing and the results so impressive that an outstanding number of papers is being published every year, with the consequence that any review on this topic becomes obsolete within a few months. Here we would like to report the latest findings on AuNPs research addressing all their functions as theranostic agents.



中文翻译:

金纳米粒子与癌症:检测、诊断和治疗

金纳米粒子 (AuNPS) 是生物医学应用中研究最多的一类纳米材料,尤其是在癌症研究领域。事实上,由于其独特的特性和高度的多功能性,它们可以在与癌症管理相关的所有方面得到利用,从早期发现到诊断和治疗。因此,AuNPs 作为生物传感器、造影剂、治疗剂已经得到了惊人的结果。它们作为有效的治疗诊断学的重要性是毋庸置疑的,但临床实践的转化受到一系列方面的阻碍,例如对人类的毒性不明确以及缺乏对可靠动物模型的深入研究。尽管如此,他们的潜在行动是如此吸引人,结果如此令人印象深刻,以至于每年都会发表大量论文,结果是任何关于这个主题的评论在几个月内就会过时。在这里,我们想报告关于 AuNPs 研究的最新发现,这些研究涉及它们作为治疗诊断剂的所有功能。

更新日期:2021-06-18
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