Abstract

We evaluated the efficacy of Tribulus terrestris in two different dosage regimes for the treatment of sexual dysfunction in pre and postmenopausal women and its effect on the vascular resistance of the clitoral artery using Power Doppler. A total of 104 women were randomly assigned to receive 94mg, three times/day (TT3) or 280mg once/day for 90 days (TT1). Evaluation was performed using FSFI and QS-F questionnaires, serum levels of prolactin, TSH, total testosterone and SHBG, and clitoral artery assessment with Power Doppler ultrasound. FSFI results demonstrated an improvement in all domains in both groups (P < 0.05) except for the “Satisfaction” in the TT3 premenopausal group. QS-F results showed a significant improvement in the mean total score in women of both reproductive phases, for both groups. Postmenopausal patients improved in all sexual domains, except for “orgasm” in the TT1 group. PI of the clitoral artery showed no difference in both reproductive phases, in both groups. We conclude that TTerrestris can be a safe alternative for the treatment of sexual dysfunction in pre and postmenopausal women as it is effective in reducing the symptoms with no side effects. Moreover, its use, increased total, free and bioavailable testosterone.

摘要

我们评估了刺蒺藜的功效在两种不同的剂量方案中，用于治疗绝经前和绝经后妇女的性功能障碍及其对使用能量多普勒的阴蒂动脉血管阻力的影响。共有 104 名女性被随机分配接受 94 毫克、每天 3 次 (TT3) 或每天 280 毫克 90 天 (TT1)。使用 FSFI 和 QS-F 问卷、催乳素、TSH、总睾酮和 SHBG 的血清水平以及使用功率多普勒超声评估阴蒂动脉进行评估。FSFI 结果表明，除了 TT3 绝经前组的“满意度”外，两组的所有领域都有改善（P < 0.05）。QS-F 结果显示，两组女性在两个生育期的平均总分都有显着提高。绝经后患者在所有性方面都有所改善，除了 TT1 组的“性高潮”。在两组中，阴蒂动脉的 PI 在两个生殖阶段均无差异。我们得出结论，TTerrestris 可以作为治疗绝经前和绝经后妇女性功能障碍的安全替代方案，因为它可有效减轻症状且无副作用。此外，它的使用增加了总的、游离的和生物可利用的睾酮。