Six dibenzo-1,4-dioxane derivatives (1–6) were isolated from the roots of a Hypericaceous plant Hypericum ascyron. Spectroscopic analyses revealed 2 and 4–6 to be new compounds. The partial racemic natures of 1–3 were concluded by chiral HPLC analyses, while 5 was confirmed to be a racemate. The absolute configurations 1–4 were deduced on the basis of ECD calculations. Biological activity evaluation of the dibenzo-1,4-dioxane derivatives along with two related compounds: hyperdioxanes A (7) and B (8), previously isolated from the same plant material by our group demonstrated that 7 exhibit an anti-HIV activity (IC₅₀ 5.3 μM, TI 7.2) while 8 showed an inhibitory effect on IL-1β production (inhibition rate: 72.3% at 6.3 μM) from LPS-stimulated microglial cells.

六二苯并-1,4-二恶烷衍生物（1 - 6）从一个Hypericaceous植物的根中分离金丝桃ascyron。分光分析显示2和4 - 6是新的化合物。的部分外消旋性质1 - 3分别通过手性HPLC分析得出的结论，而5被证实为外消旋体。绝对构型1 – 4是根据 ECD 计算推导出来的。二苯并 1,4-二恶烷衍生物以及两种相关化合物的生物活性评估：高二恶烷 A ( 7 ) 和 B ( 8 ))，我们小组之前从同一植物材料中分离出的结果表明，7 种表现出抗 HIV 活性（IC ₅₀ 5.3 μM，TI 7.2），而8 种表现出对 IL-1β 产生的抑制作用（抑制率：6.3 μM 时为 72.3% ) 来自 LPS 刺激的小胶质细胞。