Objective. Inflammation and pain are involved in the pathophysiology of various clinical conditions. This investigation aims to probe the analgesic and anti-inflammatory activity of Maltoamide F. Methods. The possible toxicity of Maltoamide F was evaluated by an acute toxicity test. To assess the anti-inflammatory and antinociceptive effects of Maltoamide F on rats, the models of carrageenan-caused paw edema, xylene-induced ear edema, arachidonic-acid- (AA-) induced ear edema, formalin-caused plantar edema, and cotton-pellet-induced granuloma were established. Levels of TNF-α, PGE-2, and IL-6 were detected by enzyme-linked immunosorbent assay (ELISA). Results. Maltoamide F was safe at oral doses of 1–10 mg/kg for rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) notably reduced carrageenan-induced edema percentage of paws in rats and decreased levels of PGE-2, IL-6, and TNF-α in homogenates of foot tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in foot tissues of formalin-induced rats. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) repressed AA-induced increase of ear thickness in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced xylene-induced weight of ear edema in rats and reduced levels of PGE-2, IL-6, and TNF-α in homogenates of ear tissues. Maltoamide F (1 mg/kg, 5 mg/kg, and 10 mg/kg) reduced levels of PGE-2, IL-6, and TNF-α in homogenates of cotton ball granuloma of cotton-pellet-induced rats. Conclusions. Maltoamide F possessed anti-inflammatory and analgesic activity in inflammatory models of rats.

中文翻译：

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Malyngamide F 在炎症大鼠模型中具有抗炎和镇痛活性

目标。炎症和疼痛涉及各种临床病症的病理生理学。本研究旨在探讨麦芽酰胺 F 的镇痛和抗炎活性。方法。Maltoamide F 的可能毒性通过急性毒性试验进行评估。为了评估麦芽酰胺 F 对大鼠、角叉菜胶引起的爪水肿、二甲苯引起的耳水肿、花生四烯酸 (AA-) 引起的耳水肿、福尔马林引起的足底水肿和棉花模型的抗炎和镇痛作用-颗粒诱导的肉芽肿被建立。TNF - α、PGE-2和IL-6水平通过酶联免疫吸附试验（ELISA）检测。结果. 麦芽酰胺 F 在大鼠口服剂量为 1-10 mg/kg 时是安全的。Maltoamide F（1 mg/kg、5 mg/kg 和 10 mg/kg）显着降低了角叉菜胶诱导的大鼠爪水肿百分比，并降低了足部匀浆中PGE-2、IL-6 和 TNF- α 的水平组织。Maltoamide F（1 mg/kg、5 mg/kg 和 10 mg/kg）可降低福尔马林诱导大鼠足部组织中PGE-2、IL-6 和 TNF- α 的水平。Maltoamide F（1 mg/kg、5 mg/kg 和 10 mg/kg）抑制 AA 诱导的大鼠耳朵厚度增加，并降低耳朵组织匀浆中PGE-2、IL-6 和 TNF- α 的水平. Maltoamide F（1 mg/kg、5 mg/kg 和 10 mg/kg）可减轻二甲苯诱导的大鼠耳水肿重量并降低 PGE-2、IL-6 和 TNF- α 的水平在耳组织匀浆中。Maltoamide F（1 mg/kg、5 mg/kg 和 10 mg/kg）降低棉球诱导大鼠棉球肉芽肿匀浆中PGE-2、IL-6 和 TNF- α 的水平。结论。Maltoamide F 在大鼠炎症模型中具有抗炎和镇痛活性。