This article presents a flexible implantable device fabricated on a polyimide (PI) catheter for targeted treatment of cardiovascular diseases. The copper (Cu) microcoil was fabricated on a PI catheter surface using the rotated UV lithography system and surrounding electroplating technology. The simulation on the magnetic fields generated from the Cu microcoil with 0.2 A current and the driving force analysis on magnetic nanoparticles (MNPs) were conducted. The results demonstrated the precise control of MNPs motions within the magnetic fields generated from the Cu microcoil fabricated on the PI surface. The maximum temperature that increased from the magnetized Cu microcoil was 2 °C at room temperature, suggesting no induced hyperthermia. Moreover, the electrical performance of Cu microcoil was excellently stable in a variety of environments, such as wet, dry, and mechanical fatigue conditions. In vivo tests displayed great biocompatibility of the fabricated device within the carotid artery of a rat model. The directional assembly of MNPs can be achieved by a Cu microcoil fabricated on the surface of a PI catheter. The fabricated device shows notable advantages in promoting the targeted therapeutic strategy of cardiovascular diseases.

中文翻译：

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一种通过聚集磁性纳米粒子靶向治疗心血管疾病的柔性可植入聚酰亚胺导管装置

本文介绍了一种在聚酰亚胺 (PI) 导管上制造的柔性可植入装置，用于心血管疾病的靶向治疗。使用旋转 UV 光刻系统和周围电镀技术在 PI 导管表面上制造铜 (Cu) 微线圈。对 Cu 微线圈产生的磁场进行了模拟，电流为 0.2 A，并对磁性纳米粒子 (MNP) 进行了驱动力分析。结果表明，在由 PI 表面制造的 Cu 微线圈产生的磁场内，MNP 运动的精确控制。从磁化的铜微线圈增加的最高温度在室温下为 2°C，这表明没有感应过热。此外，Cu微线圈的电气性能在各种环境下都非常稳定，体内测试表明，所制造的装置在大鼠模型的颈动脉内具有很好的生物相容性。MNPs 的定向组装可以通过在 PI 导管表面制造的 Cu 微线圈来实现。所制造的装置在促进心血管疾病的靶向治疗策略方面显示出显着优势。