Alcohol dehydrogenase iron containing 1 (ADHFE1) encodes a hydroxyacid-oxoacid transhydrogenase participating in multiple biological processes. The role of ADHFE1 in cancer has not been fully uncovered. Herein, we performed data analysis to investigate the expression of ADHFE1 and the underlying regulatory mechanisms, its relationship with cancer patients’ survival, and the relevant pathways in cancer. A range of recognized, web-available databases and bioinformatics tools were used in this in silico study. We found that ADHFE1 was frequently downregulated and hypermethylated in various cancer cell lines and tissue samples. High expression of ADHFE1 was positively associated with favorable patient prognosis in breast, colon, and gastric cancers. Pathway analysis revealed its potential role in cancer-related biological processes, including energy metabolism, DNA replication, and cell cycle regulation. AHDFE1 mRNA expression and DNA methylation can potentially be used as diagnostic markers in cancer and might be of great value in predicting the survival of patients with cancer.

中文翻译：

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ADHFE1是癌症患者生存的相关因素

含铁醇脱氢酶 1 (ADHFE1) 编码一种参与多种生物过程的羟基酸-含氧酸转氢酶。ADHFE1 在癌症中的作用尚未完全揭示。在此，我们进行数据分析以研究 ADHFE1 的表达及其潜在调控机制、其与癌症患者生存的关系以及癌症中的相关途径。在这项计算机模拟研究中使用了一系列公认的网络可用数据库和生物信息学工具。我们发现 ADHFE1 在各种癌细胞系和组织样本中经常被下调和高甲基化。ADHFE1 的高表达与乳腺癌、结肠癌和胃癌患者的良好预后呈正相关。通路分析揭示了其在癌症相关生物过程中的潜在作用，包括能量代谢、DNA复制和细胞周期调节。AHDFE1 mRNA 表达和 DNA 甲基化可能被用作癌症的诊断标志物，并且可能在预测癌症患者的存活率方面具有重要价值。