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Metal-Coordinated Supramolecular Self-Assemblies for Cancer Theranostics
Advanced Science ( IF 14.3 ) Pub Date : 2021-06-18 , DOI: 10.1002/advs.202101101 Jiating Xu 1 , Jun Wang 1 , Jin Ye 1 , Jiao Jiao 1 , Zhiguo Liu 1 , Chunjian Zhao 1 , Bin Li 1 , Yujie Fu 1
Advanced Science ( IF 14.3 ) Pub Date : 2021-06-18 , DOI: 10.1002/advs.202101101 Jiating Xu 1 , Jun Wang 1 , Jin Ye 1 , Jiao Jiao 1 , Zhiguo Liu 1 , Chunjian Zhao 1 , Bin Li 1 , Yujie Fu 1
Affiliation
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Metal-coordinated supramolecular nanoassemblies have recently attracted extensive attention as materials for cancer theranostics. Owing to their unique physicochemical properties, metal-coordinated supramolecular self-assemblies can bridge the boundary between traditional inorganic and organic materials. By tailoring the structural components of the metal ions and binding ligands, numerous multifunctional theranostic nanomedicines can be constructed. Metal-coordinated supramolecular nanoassemblies can modulate the tumor microenvironment (TME), thus facilitating the development of TME-responsive nanomedicines. More importantly, TME-responsive organic–inorganic hybrid nanomaterials can be constructed in vivo by exploiting the metal-coordinated self-assembly of a variety of functional ligands, which is a promising strategy for enhancing the tumor accumulation of theranostic molecules. In this review, recent advancements in the design and fabrication of metal-coordinated supramolecular nanomedicines for cancer theranostics are highlighted. These supramolecular compounds are classified according to the order in which the coordinated metal ions appear in the periodic table. Furthermore, the prospects and challenges of metal-coordinated supramolecular self-assemblies for both technical advances and clinical translation are discussed. In particular, the superiority of TME-responsive nanomedicines for in vivo coordinated self-assembly is elaborated, with an emphasis on strategies that enhance the accumulation of functional components in tumors for an ideal theranostic outcome.
中文翻译：
用于癌症治疗学的金属配位超分子自组装体
金属配位超分子纳米组件作为癌症治疗诊断材料最近引起了广泛的关注。由于其独特的物理化学性质，金属配位超分子自组装体可以弥合传统无机和有机材料之间的界限。通过调整金属离子和结合配体的结构成分，可以构建许多多功能治疗诊断纳米药物。金属配位超分子纳米组件可以调节肿瘤微环境（TME），从而促进TME响应性纳米药物的开发。更重要的是，通过利用多种功能配体的金属配位自组装，可以在体内构建TME响应的有机-无机杂化纳米材料，这是增强治疗诊断分子肿瘤积累的一种有前景的策略。在这篇综述中，重点介绍了用于癌症治疗诊断的金属配位超分子纳米药物的设计和制造的最新进展。这些超分子化合物根据配位金属离子在元素周期表中出现的顺序进行分类。此外，还讨论了金属配位超分子自组装在技术进步和临床转化方面的前景和挑战。特别是，阐述了 TME 响应性纳米药物在体内协调自组装方面的优越性，重点是增强肿瘤中功能成分积累的策略，以获得理想的治疗诊断结果。
更新日期：2021-08-19
中文翻译：
用于癌症治疗学的金属配位超分子自组装体
金属配位超分子纳米组件作为癌症治疗诊断材料最近引起了广泛的关注。由于其独特的物理化学性质，金属配位超分子自组装体可以弥合传统无机和有机材料之间的界限。通过调整金属离子和结合配体的结构成分，可以构建许多多功能治疗诊断纳米药物。金属配位超分子纳米组件可以调节肿瘤微环境（TME），从而促进TME响应性纳米药物的开发。更重要的是，通过利用多种功能配体的金属配位自组装，可以在体内构建TME响应的有机-无机杂化纳米材料，这是增强治疗诊断分子肿瘤积累的一种有前景的策略。在这篇综述中，重点介绍了用于癌症治疗诊断的金属配位超分子纳米药物的设计和制造的最新进展。这些超分子化合物根据配位金属离子在元素周期表中出现的顺序进行分类。此外，还讨论了金属配位超分子自组装在技术进步和临床转化方面的前景和挑战。特别是，阐述了 TME 响应性纳米药物在体内协调自组装方面的优越性，重点是增强肿瘤中功能成分积累的策略，以获得理想的治疗诊断结果。
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