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Aerobic iron-catalyzed site-selective C(sp3)–C(sp3) bond cleavage in N-heterocycles
Catalysis Communications ( IF 3.4 ) Pub Date : 2021-06-18 , DOI: 10.1016/j.catcom.2021.106333 David K. Leonard , Wu Li , Nils Rockstroh , Kathrin Junge , Matthias Beller
中文翻译:
有氧铁催化的位点选择性 C(sp 3 ) – N-杂环中的C(sp 3 ) 键断裂
更新日期:2021-06-22
Catalysis Communications ( IF 3.4 ) Pub Date : 2021-06-18 , DOI: 10.1016/j.catcom.2021.106333 David K. Leonard , Wu Li , Nils Rockstroh , Kathrin Junge , Matthias Beller
The kinetic and thermodynamic stability of C(sp3)–C(sp3) bonds makes the site-selective activation of these motifs a real synthetic challenge. In view of this, herein a site-selective method of C(sp3)–C(sp3) bond scission of amines, specifically morpholine and piperazine derivatives, using a cheap iron catalyst and air as a sustainable oxidant is reported. Furthermore, a statistical design of experiments (DoE) is used to evaluate multiple reaction parameters thereby allowing for the rapid development of a catalytic process.
中文翻译:
有氧铁催化的位点选择性 C(sp 3 ) – N-杂环中的C(sp 3 ) 键断裂
C(sp 3 )–C(sp 3 ) 键的动力学和热力学稳定性使这些基序的位点选择性激活成为真正的合成挑战。鉴于此,本文报道了一种使用廉价铁催化剂和空气作为可持续氧化剂的胺,特别是吗啉和哌嗪衍生物的 C(sp 3 )–C(sp 3 ) 键断裂的位点选择性方法。此外,实验统计设计 (DoE) 用于评估多个反应参数,从而允许催化过程的快速发展。