Background

There is a lack of information on changes in hospital admission rates for childhood-onset schizophrenia (COS), or on patient characteristics, to inform clinical research and health service provision.

Aims

To report age- and sex-specific incidence rates of hospital admissions and day patient care for schizophrenia (ICD-10 F20) and non-affective psychosis (ICD-10 F20-29), by year of occurrence and age, in childhood and adolescence.

Methods

Population-based study using person-linked data for England (available 2001–2016); time-periods in single years and 4-year groups.

Results

Hospitalised incidence for schizophrenia increased with increasing age, from 0.03 (95% confidence interval (CI) 0.02–0.05) and 0.01 (0–0.01) per 100,000 in, respectively, males and females aged 5–12 years, to 3.67 (3.44–3.91) in males and 1.58 (1.43–1.75) in females aged 13–17 years. There was no gender difference in hospitalised incidence rates in children aged 5–12, but in 13–17 years old, there was a male excess. Rates for schizophrenia were stable over time in 5–12 years old. In ages 13–17, rates for schizophrenia decreased between 2001–2004 and 2013–2016 in males, from 6.65 (6.04–7.31) down to 1.40 (1.13–1.73), and in females from 2.42 (2.05–2.83) to 1.18 (0.92–1.48). The hospitalisation rates for schizophrenia and non-affective psychosis, combined, in 13–17 years old decreased in males from 14.20 (13.30–15.14) in 2001–2004 to 10.77 (9.97–11.60) in 2013–2016, but increased in females from 7.49 (6.83–8.20) to 10.16 (9.38–11.00).

Conclusions

The study confirms that childhood-onset schizophrenia is extremely rare, with only 32 cases identified over a 15-year period in the whole of England. The incidence of schizophrenia and non-affective psychosis increased substantially in adolescence; however, the marked reduction in the proportion of those diagnosed with schizophrenia in this age group suggests a possible change in diagnostic practice.

中文翻译：

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英国儿童和青少年精神分裂症入院的全国记录关联研究

背景

缺乏有关儿童期精神分裂症 (COS) 住院率或患者特征变化的信息，无法为临床研究和卫生服务提供提供信息。

宗旨

按发生年份和年龄，报告儿童和青春期精神分裂症 (ICD-10 F20) 和非情感性精神病 (ICD-10 F20-29) 的住院和日间病人护理的年龄和性别特定发病率.

方法

使用英格兰人相关数据的基于人口的研究（2001-2016 年可用）；单年和 4 年组的时间段。

结果

精神分裂症的住院发病率随着年龄的增长而增加，在 5-12 岁的男性和女性中，分别从 0.03（95% 置信区间 (CI) 0.02-0.05）和 0.01（0-0.01）每 100,000 增加到 3.67（3.44-0.01） 13-17 岁男性为 3.91)，女性为 1.58 (1.43-1.75)。5-12岁儿童住院发病率无性别差异，13-17岁男性多于男性。随着时间的推移，5-12 岁的精神分裂症发病率保持稳定。2001-2004 年和 2013-2016 年间，13-17 岁男性的精神分裂症发病率从 6.65（6.04-7.31）下降到 1.40（1.13-1.73），女性从 2.42（2.05-2.83）下降到 1.18（ 0.92–1.48）。精神分裂症和非情感性精神病的住院率在 13-17 岁男性中从 2001-2004 年的 14.20（13.30-15.14）下降到 10.77（9.97-11。

结论

该研究证实，儿童期发病的精神分裂症极为罕见，在整个英格兰 15 年期间仅发现 32 例。精神分裂症和非情感性精神病的发病率在青春期大幅增加；然而，这个年龄组中被诊断患有精神分裂症的人的比例显着下降表明诊断实践可能发生变化。