Gene expression and translation have been extensively studied in human postmortem brain tissue from subjects with psychiatric disease. Posttranslational modifications have received less attention despite their implication by unbiased genetic studies and importance in regulating neuronal and circuit function. Here we review the rationale for studying posttranslational modifications in psychiatric disease, recent findings in human postmortem tissue, the required controls for these types of studies, and highlight the emerging mass spectrometry approaches transforming this research direction.

中文翻译：

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研究神经精神疾病的翻译后修饰：人类死后大脑研究的下一个前沿


基因表达和翻译已在患有精神疾病的人类死后脑组织中进行了广泛研究。尽管翻译后修饰受到公正的遗传学研究的影响以及在调节神经元和回路功能中的重要性，但它受到的关注较少。在这里，我们回顾了研究精神疾病翻译后修饰的基本原理、人类死后组织的最新发现、此类研究所需的对照，并重点介绍了改变这一研究方向的新兴质谱方法。