Breast cancer risk reduction has been validated by large-scale clinical trials, but uptake remains low. A risk communication tool could provide personalized risk-reduction information for high-risk women. A low-literacy-friendly, visual, and personalized tool was designed as part of the Women Informed to Screen Depending On Measures of risk (WISDOM) study. The tool integrates genetic, polygenic, and lifestyle factors, and quantifies the risk-reduction from undertaking medication and lifestyle interventions. The development and design process utilized feedback from clinicians, decision-making scientists, software engineers, and patient advocates. We piloted the tool with 17 study participants, collecting quantitative and qualitative feedback. Overall, participants felt they better understood their personalized breast cancer risk, were motivated to reduce their risk, and considered lifestyle interventions. The tool will be used to evaluate whether risk-based screening leads to more informed decisions and higher uptake of risk-reduction interventions among those most likely to benefit.

大规模临床试验已证实降低乳腺癌风险，但使用率仍然较低。风险沟通工具可以为高风险女性提供个性化的风险降低信息。作为女性根据风险测量信息进行筛查 (WISDOM) 研究的一部分，设计了一种适合低识字率的可视化个性化工具。该工具整合了遗传、多基因和生活方式因素，并量化了采取药物和生活方式干预措施所降低的风险。开发和设计过程利用了临床医生、决策科学家、软件工程师和患者倡导者的反馈。我们对 17 名研究参与者试用了该工具，收集定量和定性反馈。总体而言，参与者认为他们更好地了解了自己的个性化乳腺癌风险，有动力降低风险，并考虑生活方式干预。该工具将用于评估基于风险的筛查是否会导致最有可能受益的人做出更明智的决策并提高风险降低干预措施的采用率。