Functional matrix membranes formed by blending hydrophilic polymers with polysulfone (PSF) can provide functional surfaces with ameliorative hydrophilicity and possess excellent antifouling resistance over a wide range of applications. Zwitterionic polymers have better antifouling properties, but their homopolymers should not be used directly because of their poor mechanical properties and strong water absorption. To solve these problems, a living radical polymerization process was used to prepare P(4VP_x-r-SBMA_y) copolymers comprising of zwitterion side chains and hydrophobic 4-vinylpyridine (4VP). The modified PSF membranes were then constructed by adding different ratios of P(4VP_x-r-SBMA_y) via phase inversion/immersion precipitation technique. The presence of 4VP and zwitterion chains of copolymer was verified by ¹H nuclear magnetic resonance (NMR) and Fourier transform infrared (FTIR) analyses, and the successful surface functionalization was further confirmed with atomic force microscopy (AFM), scanning electron microscopy (SEM) and water contact angle measurement. Protein adsorption, bacterium adhesion and cell attachment assays showed that the functional PSF membrane surfaces exhibited superior hydrophilicity and antifouling performance.

通过将亲水聚合物与聚砜 (PSF) 混合形成的功能性基质膜可以提供具有改善亲水性的功能性表面，并在广泛的应用范围内具有出色的抗污性。两性离子聚合物具有较好的防污性能，但它们的均聚物机械性能差，吸水性强，不宜直接使用。为了解决这些问题，采用活性自由基聚合工艺制备了包含两性离子侧链和疏水性4-乙烯基吡啶(4VP)的P(4VP _x - r -SBMA _y )共聚物。然后通过添加不同比例的 P(4VP _x - r -SBMA _y) 通过反相/浸渍沉淀技术。通过¹ H 核磁共振 (NMR) 和傅里叶变换红外 (FTIR) 分析验证了共聚物的 4VP 和两性离子链的存在，并通过原子力显微镜 (AFM)、扫描电子显微镜 (SEM) 进一步证实了成功的表面功能化) 和水接触角测量。蛋白质吸附、细菌粘附和细胞粘附试验表明，功能性 PSF 膜表面表现出优异的亲水性和防污性能。