Introduction. The true impact of prediabetes and type-2 diabetes in patients with COVID-19 remains unknown, with studies thus far providing conflicting evidence. Methods. This is a single-center retrospective observational study involving 843 hospitalized patients with SARS-CoV-2 infection. Primary outcomes, mortality, and mechanical ventilation use were compared among the three groups: control, prediabetes, and type-2 diabetes. Binomial regression analysis was used to determine predictors of mortality and mechanical ventilation requirement. Results. Age was a significant predictor of mortality. On stratifying our patients based on their age, older patients aged 55 years and above had no difference in mortality or mechanical ventilation requirement among the three groups of control, prediabetes, and type-2 diabetes. However, among the younger population aged less than 55 years, patients with type-2 diabetes had significantly higher mortality as compared with patients in control and prediabetes groups (27% vs 12.5% vs 9%, ). Additionally, newly diagnosed type-2 diabetes patients demonstrated lower mortality rate in comparison to previously known type-2 diabetes patients (18% vs 40%, ). Outcomes in the prediabetes group were similar to that in the control group. Admission hyperglycemia was associated with higher mortality regardless of diabetes status. Conclusion. In older patients aged 55 years and above, status of type-2 diabetes does not influence their mortality. However, in younger patients aged less than 55 years, the presence of type-2 diabetes is an important driver of mortality. Newly diagnosed type-2 diabetes, in comparison with previously diagnosed type-2 diabetes, may have better survival. Presence of prediabetes did not affect outcomes in patients with COVID-19 infection.

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糖尿病前期和 2 型糖尿病对 COVID-19 患者预后的影响

介绍。前驱糖尿病和 2 型糖尿病对 COVID-19 患者的真正影响仍然未知，迄今为止的研究提供了相互矛盾的证据。方法。这是一项单中心回顾性观察研究，涉及 843 名 SARS-CoV-2 感染住院患者。比较三组的主要结局、死亡率和机械通气使用情况：对照组、糖尿病前期和 2 型糖尿病。二项式回归分析用于确定死亡率和机械通气需求的预测因素。结果. 年龄是死亡率的重要预测因素。根据年龄对我们的患者进行分层，55 岁及以上的老年患者在对照组、糖尿病前期和 2 型糖尿病三组之间的死亡率或机械通气需求方面没有差异。然而，在年龄小于 55 岁的年轻人群中，2 型糖尿病患者的死亡率显着高于对照组和糖尿病前期患者（27% vs 12.5% vs 9%，... ）。此外，与先前已知的 2 型糖尿病患者相比，新诊断的 2 型糖尿病患者的死亡率较低（18% 对 40%，... ）。糖尿病前期组的结果与对照组相似。无论糖尿病状态如何，入院时高血糖与更高的死亡率相关。结论。在 55 岁及以上的老年患者中，2 型糖尿病的状态不影响他们的死亡率。然而，在年龄小于 55 岁的年轻患者中，2 型糖尿病的存在是死亡率的重要驱动因素。与先前诊断的 2 型糖尿病相比，新诊断的 2 型糖尿病可能有更好的生存率。前驱糖尿病的存在不影响 COVID-19 感染患者的预后。