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Reduced neutralization of SARS-CoV-2 B.1.617 by vaccine and convalescent serum
Cell ( IF 45.5 ) Pub Date : 2021-06-17 , DOI: 10.1016/j.cell.2021.06.020
Chang Liu 1 , Helen M Ginn 2 , Wanwisa Dejnirattisai 3 , Piyada Supasa 3 , Beibei Wang 3 , Aekkachai Tuekprakhon 3 , Rungtiwa Nutalai 3 , Daming Zhou 4 , Alexander J Mentzer 5 , Yuguang Zhao 4 , Helen M E Duyvesteyn 4 , César López-Camacho 3 , Jose Slon-Campos 3 , Thomas S Walter 4 , Donal Skelly 6 , Sile Ann Johnson 7 , Thomas G Ritter 8 , Chris Mason 8 , Sue Ann Costa Clemens 9 , Felipe Gomes Naveca 10 , Valdinete Nascimento 10 , Fernanda Nascimento 10 , Cristiano Fernandes da Costa 11 , Paola Cristina Resende 12 , Alex Pauvolid-Correa 13 , Marilda M Siqueira 12 , Christina Dold 14 , Nigel Temperton 15 , Tao Dong 16 , Andrew J Pollard 14 , Julian C Knight 17 , Derrick Crook 18 , Teresa Lambe 19 , Elizabeth Clutterbuck 14 , Sagida Bibi 14 , Amy Flaxman 19 , Mustapha Bittaye 19 , Sandra Belij-Rammerstorfer 19 , Sarah C Gilbert 19 , Tariq Malik 20 , Miles W Carroll 21 , Paul Klenerman 22 , Eleanor Barnes 22 , Susanna J Dunachie 23 , Vicky Baillie 24 , Natali Serafin 24 , Zanele Ditse 24 , Kelly Da Silva 24 , Neil G Paterson 2 , Mark A Williams 2 , David R Hall 2 , Shabir Madhi 24 , Marta C Nunes 24 , Philip Goulder 25 , Elizabeth E Fry 4 , Juthathip Mongkolsapaya 26 , Jingshan Ren 4 , David I Stuart 27 , Gavin R Screaton 1
Affiliation  

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has undergone progressive change, with variants conferring advantage rapidly becoming dominant lineages, e.g., B.1.617. With apparent increased transmissibility, variant B.1.617.2 has contributed to the current wave of infection ravaging the Indian subcontinent and has been designated a variant of concern in the United Kingdom. Here we study the ability of monoclonal antibodies and convalescent and vaccine sera to neutralize B.1.617.1 and B.1.617.2, complement this with structural analyses of Fab/receptor binding domain (RBD) complexes, and map the antigenic space of current variants. Neutralization of both viruses is reduced compared with ancestral Wuhan-related strains, but there is no evidence of widespread antibody escape as seen with B.1.351. However, B.1.351 and P.1 sera showed markedly more reduction in neutralization of B.1.617.2, suggesting that individuals infected previously by these variants may be more susceptible to reinfection by B.1.617.2. This observation provides important new insights for immunization policy with future variant vaccines in non-immune populations.



中文翻译:


疫苗和恢复期血清对 SARS-CoV-2 B.1.617 的中和作用减少



严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 已经发生了渐进性变化,具有优势的变体迅速成为优势谱系,例如 B.1.617。由于传播性明显增强,B.1.617.2 变种导致了当前肆虐印度次大陆的感染浪潮,并已被指定为英国关注的变种。在这里,我们研究单克隆抗体以及恢复期和疫苗血清中和 B.1.617.1 和 B.1.617.2 的能力,通过 Fab/受体结合域 (RBD) 复合物的结构分析对其进行补充,并绘制当前的抗原空间图变体。与祖先的武汉相关毒株相比,这两种病毒的中和作用均有所减少,但没有证据表明 B.1.351 中存在广泛的抗体逃逸。然而,B.1.351 和 P.1 血清显示 B.1.617.2 的中和作用显着减少,表明先前被这些变体感染的个体可能更容易被 B.1.617.2 再次感染。这一观察结果为非免疫人群未来变异疫苗的免疫政策提供了重要的新见解。

更新日期:2021-08-05
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