Three new quinoline alkaloids, 4-acetyl-6-methyl-7-(3-methyl-2-oxobut-3-enyl)quinolin-2(1H)-one (1), 4-acetyl-5-methyl-7-(3-methyl-2-oxobut-3-enyl)quinolin-2(1H)-one (2), and 4-acetyl-6-methyl-7-prenylquinolin-2(1H)-one (3) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were elucidated by spectroscopic methods, including extensive 1H, 13C, and 2D-NMR techniques. Compounds 1-3 were also tested for their anti-rotavirus activity. Compounds 1-3 exhibited potent anti-rotavirus activity with therapeutic index (TI) valves of 17.6, 15.0, and 23.6 respectively.

中文翻译：

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三种新型抗轮状病毒喹啉类全株生物碱

三种新型喹啉生物碱，4-acetyl-6-methyl-7-(3-methyl-2-oxobut-3-enyl)quinolin-2(1 H )-one ( 1 ), 4-acetyl-5-methyl-7 -(3-methyl-2-oxobut-3-enyl)quinolin-2(1 H )-one ( 2 ), and 4-acetyl-6-methyl-7-prenylquinolin-2(1 H )-one ( 3 )是从Thalictrumglunosissimum的全株中分离得到的。它们的结构通过光谱方法阐明，包括广泛的1 H、13 C 和 2D-​​NMR 技术。化合物1 - 3也测试其抗轮状病毒活性。化合物1 - 3 显示出有效的抗轮状病毒活性，治疗指数 (TI) 瓣膜分别为 17.6、15.0 和 23.6。