Soft network materials represent a class of emerging cellular materials that have well-organized micro-architectures inspired by network microstructures found in many soft biological tissues. Apart from a good combination of low density, high stretchability and high air permeability, the high degree of design flexibility of soft network materials allows precise customization of mechanical properties by rationally tailoring their microstructural architecture and optimizing selections of constituent materials. These intriguing properties have enabled a range of promising applications in cutting-edge technologies, such as bio-integrated electronics and regenerative medicine. This review summarizes the latest progress in the design and fabrication of soft network materials, as well as their representative applications in biomedical devices, tissue engineering and other areas. It focuses on fundamental principles, design concepts and fabrication techniques of soft network materials that consist of either periodically or randomly distributed microstructures. Rational designs of these soft network materials result in customized mechanical properties that mimic or even exceed those of soft biological tissues. Finally, perspectives on the remaining challenges and open opportunities are provided.

软网络材料代表了一类新兴的细胞材料，它们具有组织良好的微结构，其灵感来自许多软生物组织中发现的网络微结构。除了低密度、高拉伸性和高透气性的良好结合外，软网络材料的高度设计灵活性允许通过合理调整其微观结构结构和优化组成材料的选择来精确定制机械性能。这些有趣的特性使得在尖端技术中的一系列有前景的应用成为可能，例如生物集成电子和再生医学。这篇综述总结了软网络材料设计和制造的最新进展，以及它们在生物医学设备中的代表性应用，组织工程等领域。它侧重于由周期性或随机分布的微结构组成的软网络材料的基本原理、设计概念和制造技术。这些软网络材料的合理设计导致定制的机械性能模仿甚至超过软生物组织的机械性能。最后，提供了对剩余挑战和开放机遇的看法。