Abstract

Because of good optical and electrical properties, TiO₂ nanoparticles are widely used in many fields of industry and medicine. To assess the effect of TiO₂ nanoparticles on mice cognitive abilities and their accumulation in different organs, daily, up to 2-month period, experimental mice were administrated with TiO₂ nanoparticles solution. Accumulation of titanium in blood, brain, liver, kidney, lungs and feces was assessed by neutron activation analysis. Cognitive abilities in mice before and after TiO₂ nanoparticles administration were evaluated in the Morris water maze behavioral test. The amount of titanium in all organs was below the limits of detection of the method and in feces it constituted 74 ± 7 µg/g. In the main Morris water maze behavioral test at the control points statistically significant differences were found in the parameters of treks between capable experimental and control animals.

中文翻译：

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TiO2 纳米颗粒在器官中的积累及其对小鼠认知能力的影响的评估

摘要

由于具有良好的光学和电学性能，TiO ₂纳米粒子被广泛应用于工业和医学的许多领域。为了评估 TiO ₂纳米颗粒对小鼠认知能力的影响及其在不同器官中的积累，每天，长达 2 个月的时间，给实验小鼠施用 TiO ₂纳米颗粒溶液。钛在血液、脑、肝、肾、肺和粪便中的积累通过中子活化分析进行评估。TiO ₂前后小鼠的认知能力在莫里斯水迷宫行为测试中评估纳米颗粒给药。所有器官中的钛含量均低于该方法的检测限，而粪便中的钛含量为 74 ± 7 µg/g。在控制点的主要莫里斯水迷宫行为测试中，在有能力的实验动物和对照动物之间的跋涉参数中发现了统计学上的显着差异。