The adult skeletal muscle fully regenerates after injury thanks to the properties of muscle stem cells that follow the adult myogenic program to replace damaged myofibers. Muscle regeneration also relies upon the coordinated actions of several other cell types, among which immune cells. Leukocytes infiltrate the damaged muscle soon after injury and support the regeneration process in a variety of ways, from the activation of muscle stem cells to the maturation of newly formed myofibers. Leukocytes also interact with other cell types such as fibroadipogenic precursors and endothelial cells. This review presents the interactions that leukocytes develop with the cells present in their vicinity and the impact they have on skeletal muscle regeneration.

由于肌肉干细胞的特性遵循成人生肌程序以替换受损的肌纤维，因此成人骨骼肌在受伤后完全再生。肌肉再生还依赖于其他几种细胞类型的协调作用，其中包括免疫细胞。白细胞在受伤后很快渗入受损肌肉，并以多种方式支持再生过程，从肌肉干细胞的激活到新形成的肌纤维的成熟。白细胞还与其他细胞类型如纤维脂肪生成前体和内皮细胞相互作用。本综述介绍了白细胞与其附近存在的细胞之间的相互作用以及它们对骨骼肌再生的影响。