Recent advances in bioinspired nano/microstructures have received attention as promising approaches with which to implement smart skin-interfacial devices for personalized health care. In situ skin diagnosis requires adaptable skin adherence and rapid capture of clinical biofluids. Here, we report a simple, all-in-one device consisting of microplungers and hydrogels that can rapidly capture biofluids and conformally attach to skin for stable, real-time monitoring of health. Inspired by the male diving beetle, the microplungers achieve repeatable, enhanced, and multidirectional adhesion to human skin in dry/wet environments, revealing the role of the cavities in these architectures. The hydrogels within the microplungers instantaneously absorb liquids from the epidermis for enhanced adhesiveness and reversibly change color for visual indication of skin pH levels. To realize advanced biomedical technologies for the diagnosis and treatment of skin, our suction-mediated device is integrated with a machine learning framework for accurate and automated colorimetric analysis of pH levels.

仿生纳米/微结构的最新进展作为实现个性化医疗保健的智能皮肤界面设备的有希望的方法而受到关注。原位皮肤诊断需要适应性强的皮肤粘附和临床生物流体的快速捕获。在这里，我们报告了一种简单的一体化设备，由微型活塞和水凝胶组成，可以快速捕获生物流体并适形地附着在皮肤上，以实现稳定、实时的健康监测。受雄性潜水甲虫的启发，微型活塞在干/湿环境中实现了对人体皮肤的可重复、增强和多向粘附，揭示了空腔在这些结构中的作用。微型活塞内的水凝胶可瞬间从表皮吸收液体以增强粘附性，并可逆地改变颜色以直观地指示皮肤的 pH 值。为了实现用于皮肤诊断和治疗的先进生物医学技术，我们的抽吸介导设备与机器学习框架相集成，可对 pH 水平进行准确和自动的比色分析。