Cutaneous mucormycosis caused by Mucor irregularis (M. irregularis) is a rare condition that typically occurs in immunocompetent patients. Herein, we describe an immunocompromised patient with cutaneous M. irregularis infection who was successfully treated with debridement combined with vacuum assisted closure (VAC) negative pressure technique and split-thickness skin grafting. We present this case owing to its complexity and rarity and the successful treatment with surgical therapy. A 58-year-old man presented to our hospital with a history of skin ulcers and eschar on the right lower leg since two months. He had been receiving methylprednisolone therapy for bullous pemphigoid that occurred five months prior to the present lesions. Histopathological examination of a right leg lesion showed broad, branching hyphae in the dermis. Fungal culture and subsequent molecular cytogenetic analysis identified the pathogen as M. irregularis. After admission, methylprednisolone was gradually tapered and systemic treatment with amphotericin B (total dose 615 mg) initiated along with others supportive therapies. However, the ulcers showed no improvement, and amphotericin B had to be discontinued owing to development of renal dysfunction. After extensive surgical debridement combined with VAC and skin grafting, his skin ulcers were healed; subsequent fungal cultures of the lesions were negative. The patient exhibited no signs of recurrence at 36-month follow-up. Twenty-six cases with M. irregularis-associated cutaneous mucormycosis in literature were reviewed.

由不规则毛霉菌（不规则毛霉菌）引起的皮肤毛霉菌病是一种罕见的疾病，通常发生在免疫功能正常的患者身上。在此，我们描述了一名患有皮肤不规则分枝杆菌的免疫功能低下患者清创联合真空辅助闭合（VAC）负压技术和分层皮肤移植成功治疗感染。我们介绍这个案例是因为它的复杂性和罕见性以及手术治疗的成功治疗。一名 58 岁男性因右小腿皮肤溃疡和焦痂 2 个月来我院就诊。他一直在接受甲基强的松龙治疗，以治疗大疱性类天疱疮，该类天疱疮发生在本病灶前五个月。右腿病变的组织病理学检查显示真皮中有广泛的分枝菌丝。真菌培养和随后的分子细胞遗传学分析确定病原体为不规则分枝杆菌. 入院后，甲泼尼龙逐渐减量，开始全身治疗两性霉素 B（总剂量 615 mg）和其他支持疗法。然而，溃疡没有改善，由于肾功能障碍的发展，两性霉素 B 不得不停用。经过广泛的手术清创结合VAC和植皮，他的皮肤溃疡愈合；随后病灶真菌培养呈阴性。患者在 36 个月的随访中没有表现出复发迹象。回顾了文献中26例不规则支原体相关皮肤毛霉菌病的病例。