Abstract

Purpose

Canadian Organization on Health Effects from Radiation Exposure (COHERE) is a government initiative to better understand biological and human health risks from ionizing radiation exposures relevant to occupational and environmental settings (<100 mGy, <6 mGy/h). It is currently a partnership between two federal agencies, Health Canada (HC) and the Canadian Nuclear Safety Commission (CNSC). COHERE’s vision is to contribute knowledge to reduce scientific uncertainties from low dose and dose-rate exposures. COHERE will advance our understanding by bridging the knowledge gap between human health risks and linkages to molecular- and cellular-level responses to radiation. Research focuses on identifying sensitive, early, and key molecular events of relevance to risk assessment.

Conclusions

The initiative will address questions of relevance to better apprize Canadians, including radiation workers and members of the public and Indigenous peoples, on health risks from low dose radiation exposure and inform radiation protection frameworks at a national and international level. Furthermore, it will support global efforts to conduct collaborative undertakings and better coordinate research. Here, we describe a historical overview of the research conducted, the strategic research agenda that outlines the scientific framework, stakeholders, opportunities to harmonize internationally, and how research outcomes will better inform communication of risk to Canadians.

中文翻译：

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COHERE – 加强加拿大政府内部在辐射研究方面的合作

 抽象的

 目的

加拿大辐射暴露对健康影响组织 (COHERE) 是一项政府倡议，旨在更好地了解与职业和环境环境相关的电离辐射暴露（<100 mGy、<6 mGy/h）所带来的生物和人类健康风险。目前它是加拿大卫生部 (HC) 和加拿大核安全委员会 (CNSC) 这两个联邦机构之间的合作伙伴关系。 COHERE 的愿景是贡献知识，减少低剂量和剂量率暴露带来的科学不确定性。 COHERE 将通过弥合人类健康风险与分子和细胞水平辐射反应之间的知识差距来增进我们的理解。研究重点是识别与风险评估相关的敏感、早期和关键分子事件。

 结论

该倡议将解决相关问题，以便更好地向加拿大人（包括辐射工作者、公众和原住民）通报低剂量辐射暴露造成的健康风险，并为国家和国际层面的辐射防护框架提供信息。此外，它将支持全球开展合作事业和更好地协调研究的努力。在这里，我们描述了所进行的研究的历史概述、概述了科学框架、利益相关者、国际协调机会的战略研究议程，以及研究成果如何更好地向加拿大人传达风险信息。