The main aim of this study was to determine physicochemical, antioxidant, and cytotoxic properties of cadmium nanoparticles (Cd NPs) produced using Artemisia persica extract combined with microwave irradiation (850 W). The obtained results showed that the Cd NPs were hexagonal in shape and their size was in the range of 11.2–18.6 nm. The attained results of antioxidant activity showed that at concentrations ranging from 10 to 2560 µg mL⁻¹, there was no considerable difference between scavenging effect of Cd NPs and ascorbic acid (p > 0.05). For A549, 3T3, HT-29, MCF-7, and U87 cells exposed to Cd NPs, the IC₅₀ was measured to be 47.2 ± 1.2 µg mL⁻¹, 10.6 ± 1 µg mL⁻¹, 133.5 ± 1.3 µg mL⁻¹, 1.8 ± 0.7 µg mL⁻¹, and 62.9 ± 3.3 µg mL⁻¹, respectively. Generally, Cd NPs exhibited lower cytotoxicity and higher antioxidant effect in comparison to cadmium ions which further studies should perform to find about the related mechanisms.

本研究的主要目的是确定使用桃蒿提取物结合微波辐射 (850 W)生产的镉纳米颗粒 (Cd NPs) 的物理化学、抗氧化和细胞毒性特性。所得结果表明，Cd NPs 呈六边形，尺寸在 11.2-18.6 nm 范围内。获得的抗氧化活性结果表明，在 10 到 2560 µg mL ^{-1 的}浓度范围内，Cd NPs 和抗坏血酸的清除效果之间没有显着差异（p  > 0.05）。对于暴露于 Cd NPs 的 A549、3T3、HT-29、MCF-7 和 U87 细胞，IC ₅₀测量值为 47.2 ± 1.2 µg mL ^-1、10.6 ± 1 µg mL ^-1、 133.5 ± 1.3 µg mL ^-1、1.8 ± 0.7 µg mL ^-1和 62.9 ± 3.3 µg mL ^-1。通常，与镉离子相比，Cd NPs 表现出较低的细胞毒性和较高的抗氧化作用，这需要进一步研究以找出相关机制。