Leukocyte recruitment is a critical step in the pathogenesis of inflammatory and immunological responses. Cell adhesion molecules (CAMs) are involved in controlling cell movements and the recruitment process, and the integrin family of CAMs plays a key role. During cell movement, integrin function is dynamically and precisely regulated. However, this balance might be broken under pathological conditions. Thus, the functional regulation and molecular mechanisms of integrins related to diseases are often a focus of research. Integrin β2 is one of the most commonly expressed integrins in leukocytes that mediates leukocyte adhesion and migration, and it plays an important role in immune responses and inflammation. In this review, we focus on specific functions of integrin β2 in leukocyte recruitment, the conformational changes and signal transduction of integrin β2 activation, and how new insights into these processes can inform future therapies for inflammation and immune diseases.

中文翻译：

---

白细胞募集中的β2整合素激活和信号转导

白细胞募集是炎症和免疫反应发病机制中的关键步骤。细胞粘附分子 (CAM) 参与控制细胞运动和募集过程，CAM 的整合素家族起着关键作用。在细胞运动过程中，整合素功能受到动态且精确的调节。然而，这种平衡可能在病理条件下被打破。因此，与疾病相关的整合素的功能调控和分子机制往往是研究的热点。整合素β2是白细胞中最常表达的整合素之一，介导白细胞粘附和迁移，在免疫反应和炎症反应中发挥重要作用。在这篇综述中，我们关注整合素 β2 在白细胞募集中的特定功能，