Pulmonary hypertension is a rare disease with high morbidity and mortality which mainly affects women of reproductive age. Despite recent advances in understanding the pathogenesis of pulmonary hypertension, the high heterogeneity in the presentation of the disease among different patients makes it difficult to make an accurate diagnosis and to apply this knowledge to effective treatments. Therefore, new studies are required to focus on translational and personalized medicine to overcome the lack of specificity and efficacy of current management. Here, we review the majority of public databases storing ‘omics’ data of pulmonary hypertension studies, from animal models to human patients. Moreover, we review some of the new molecular mechanisms involved in the pathogenesis of pulmonary hypertension, including non-coding RNAs and the application of ‘omics’ data to understand this pathology, hoping that these new approaches will provide insights to guide the way to personalized diagnosis and treatment.

肺动脉高压是一种罕见的疾病，发病率和死亡率都很高，主要影响育龄妇女。尽管最近在理解肺动脉高压的发病机制方面取得了进展，但不同患者之间疾病表现的高度异质性使得难以做出准确的诊断并将这些知识应用于有效的治疗。因此，需要新的研究关注转化和个性化医学，以克服当前管理缺乏特异性和有效性的问题。在这里，我们回顾了大多数存储肺动脉高压研究“组学”数据的公共数据库，从动物模型到人类患者。此外，我们回顾了一些涉及肺动脉高压发病机制的新分子机制，