Adiponectin (AdipoQ), a hormone abundantly secreted by adipose tissues, has multiple beneficial functions, including insulin sensitization as well as lipid and glucose metabolism. It has been reported that bone controls energy metabolism through an endocrine-based mechanism. In this study, we observed that bone also acts as an important endocrine source for AdipoQ, and its capacity in osteoblasts is controlled by the forkhead box P1 (FOXP1) transcriptional factor. Deletion of the Foxp1 gene in osteoblasts led to augmentation of AdipoQ levels accompanied by fueled energy expenditure in adipose tissues. In contrast, overexpression of Foxp1 in bones impaired AdipoQ secretion and restrained energy consumption. Chromatin immunoprecipitation sequencing (ChIP-seq) analysis revealed that AdipoQ expression, which increases as a function of bone age, is directly controlled by FOXP1. Our results indicate that bones, especially aged bones, provide an important source of a set of endocrine factors, including AdipoQ, that control body metabolism. © 2021 American Society for Bone and Mineral Research (ASBMR).

中文翻译：

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成骨细胞中的叉头盒 P1 (Foxp1) 调节骨量增加和脂肪组织能量代谢

脂联素 (AdipoQ) 是一种由脂肪组织大量分泌的激素，具有多种有益功能，包括胰岛素致敏以及脂质和葡萄糖代谢。据报道，骨骼通过基于内分泌的机制控制能量代谢。在这项研究中，我们观察到骨骼也是 AdipoQ 的重要内分泌来源，其在成骨细胞中的能力受叉头盒 P1 (FOXP1) 转录因子控制。成骨细胞中Foxp1基因的缺失导致 AdipoQ 水平的增加，伴随着脂肪组织中能量消耗的增加。相比之下，Foxp1在骨骼中的过度表达会损害 AdipoQ 的分泌并抑制能量消耗。染色质免疫沉淀测序（ChIP-seq）分析表明AdipoQ表达随骨龄增加而增加，由FOXP1直接控制。我们的研究结果表明，骨骼，尤其是老化的骨骼，是一组控制身体新陈代谢的内分泌因子（包括 AdipoQ）的重要来源。© 2021 美国骨与矿物研究学会 (ASBMR)。