Chlorinated derivatives of bisphenol A (ClxBPA) are endocrine disruptors that have seldom been studied. The aim was to assess the determinants of ClxBPA presence and bisphenol A (BPA) concentration in colostrum fluid. Pregnant women participating in the EDDS cohort study (France, 2011–2014) received two visits at home during their pregnancies, the objectives being to inform ourselves on their sociodemographic characteristics and consumption habits and to collect their urine samples. A colostrum sample was collected at delivery. All samples were analyzed using solid-phase extraction coupled with ultra-high-performance liquid chromatography isotope dilution tandem mass spectrometry method. Among 100 pregnant women, 32% had at least one ClxBPA detected in their colostrum fluid, 19% monochlorobisphenol-A, 23% dichlorobisphenol-A, 16% trichlorobisphenol-A and 2% tetrachlorobisphenol-A. After adjustment for sociodemographic factors, sample collection between 24 and 48 h after delivery was associated with lower ClxBPA presence in colostrum (OR = 0.06, 95%CI (0.01, 0.66) compared to colostrum collected during the first 24 h. BPA was detected in 60 colostrum fluids (61%) with mean concentrations of 2.1 ± 6.9 ng/mL. After adjustment, BPA was higher among women currently smoking during the third trimester (β = 1.20 95%CI (0.30, 2.09)) and lower when the sample was collected between 24 and 48 h after delivery (β = -0.72 95%CI (-1.43, -0.02)) compared to colostrum collection during the first 24 h after delivery. Sociodemographic factors, water exposure and food consumption were not associated with presence of ClxBPA in colostrum and concentration of BPA. Confirmation of these results with further powerful studies are needed, particularly those on kinetic investigation of ClxBPA excretion in colostrum would be interesting to improve storage condition’s knowledge.

双酚 A 的氯化衍生物 (ClxBPA) 是很少被研究的内分泌干扰物。目的是评估初乳液中 ClxBPA 存在和双酚 A (BPA) 浓度的决定因素。参与 EDDS 队列研究（法国，2011-2014 年）的孕妇在怀孕期间接受了两次家访，目的是了解她们的社会人口学特征和消费习惯，并收集她们的尿液样本。交付时收集初乳样品。所有样品均采用固相萃取结合超高效液相色谱同位素稀释串联质谱法进行分析。在 100 名孕妇中，32% 的人的初乳液中至少检测到一种 ClxBPA，19% 的单氯双酚 A，23% 的二氯双酚 A，16% 三氯双酚-A 和 2% 四氯双酚-A。在调整社会人口因素后，分娩后 24 至 48 小时之间的样本收集与初乳中较低的 ClxBPA 存在相关（OR = 0.06，95%CI (0.01, 0.66) 与前 24 小时收集的初乳相比。BPA 在60 份初乳液 (61%)，平均浓度为 2.1 ± 6.9 ng/mL。调整后，目前在妊娠晚期吸烟的女性的 BPA 较高 (β = 1.20 95%CI (0.30, 2.09))，而样本中的 BPA 较低与分娩后第一个 24 小时内收集初乳相比，分娩后 24 至 48 小时收集 (β = -0.72 95% CI (-1.43, -0.02))。社会人口学因素、水暴露和食物消耗与存在无关初乳中 ClxBPA 的含量和 BPA 的浓度。