Despite the favorable survival rates of childhood B-cell acute lymphoblastic leukemia (B-ALL), a significant number of patients present a dismal prognosis. Forkhead box P3 (FOXP3), a marker of regulatory T cells, functions as a transcription factor involved in immune cell regulation, and its expression correlates with prognosis in many malignancies. Therefore, this study aimed to assess the relative gene expression level of FOXP3 in childhood B-ALL and to detect its prognostic utility.

中文翻译：

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Forkhead box P3在儿童B细胞急性淋巴细胞白血病中的相对表达及预后意义

尽管儿童 B 细胞急性淋巴细胞白血病 (B-ALL) 的存活率很高，但仍有大量患者预后不佳。Forkhead box P3 ( FOXP3 ) 是调节性 T 细胞的标志物，作为参与免疫细胞调节的转录因子发挥作用，其表达与许多恶性肿瘤的预后相关。因此，本研究旨在评估儿童 B-ALL 中FOXP3的相对基因表达水平并检测其预后效用。