Extractable Organofluorine Analysis in Pooled Human Serum and Placental Tissue Samples from an Austrian Subpopulation—A Mass Balance Analysis Approach,Environmental Science & Technology

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Extractable Organofluorine Analysis in Pooled Human Serum and Placental Tissue Samples from an Austrian Subpopulation—A Mass Balance Analysis Approach
Environmental Science & Technology ( IF 10.8 ) Pub Date : 2021-06-16 , DOI: 10.1021/acs.est.1c00883
Andreas-Marius Kaiser _{1,

2} , Martin Forsthuber _{2,

3} , Rudolf Aro ₄ , Anna Kärrman ₄ , Claudia Gundacker ₂ , Harald Zeisler ₅ , Philipp Foessleitner ₆ , Hans Salzer ₇ , Christina Hartmann ₁ , Maria Uhl ₁ , Leo W Y Yeung ₄

Affiliation

Embryos and fetuses are of major concern due to their high vulnerability. Previous studies demonstrated that human exposure to per- and polyfluoroalkyl substances (PFAS) may be underestimated because only a limited number of known PFAS can be measured. This investigation studied the total PFAS exposure by measuring the extractable organofluorine (EOF) in pooled maternal serum, placental tissue, and cord serum samples (total number of pooled samples: n = 45). The EOF was analyzed using combustion ion chromatography, and the concentrations of known PFAS were determined using ultraperformance liquid chromatography coupled with a tandem mass spectrometer. Using a mass balance analysis approach, the amount of unknown PFAS was estimated between the levels of known PFAS and EOF. The EOF levels ranged from 2.85 to 7.17 ng F/mL (21 PFAS were quantified) in the maternal serum, from 1.02 to 1.85 ng F/g (23 PFAS were quantified) in the placental tissue, and from 1.2 to 2.10 ng F/mL (18 PFAS were quantified) in the cord serum. An average of 24, 51, and 9% of EOF is unidentified in the maternal serum, placental tissue, and cord serum, respectively. The results show that the levels of unidentified EOF are higher in the placental tissue, suggesting accumulation or potential transformation of precursors in the placenta.

中文翻译：

来自奥地利亚群的混合人血清和胎盘组织样本中的可提取有机氟分析——质量平衡分析方法

胚胎和胎儿由于其高度脆弱性而备受关注。先前的研究表明，人类对全氟和多氟烷基物质 (PFAS) 的暴露可能被低估，因为只能测量有限数量的已知 PFAS。该调查通过测量母体血清、胎盘组织和脐带血清样本中的可提取有机氟 (EOF) 来研究总 PFAS 暴露（合并样本总数：n= 45）。使用燃烧离子色谱分析 EOF，使用超高效液相色谱与串联质谱仪测定已知 PFAS 的浓度。使用质量平衡分析方法，在已知 PFAS 和 EOF 的水平之间估计未知 PFAS 的数量。母体血清中的 EOF 水平范围为 2.85 至 7.17 ng F/mL（量化了 21 种 PFAS），胎盘组织中的 EOF 水平为 1.02 至 1.85 ng F/g（量化了 23 种 PFAS），以及 1.2 至 2.10 ng F/ mL（定量 18 PFAS）在脐带血清中。平均分别有 24%、51% 和 9% 的 EOF 在母体血清、胎盘组织和脐带血清中未被鉴定。结果表明，胎盘组织中未鉴定的EOF水平较高，

更新日期：2021-07-06

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