Clitoria ternatia L. (CT) has been reported to have anti-inflammatory and antioxidant effects. This study investigated the effect of CT aqueous flower extract on blood pressure and renal alterations in N^ω-nitro-l-arginine methyl ester hydrochloride (l-NAME)-induced hypertensive rats. Male Sprague Dawley rats received l-NAME in drinking water and were treated with CT flower extract or lisinopril. CT aqueous flower extract and lisinopril alleviated l-NAME-induced hypertension (p < 0.05). Glomerular extracellular matrix accumulation, renal fibrosis, and increased serum creatinine levels were observed in l-NAME-induced hypertensive rats and attenuated by CT flower extract or lisinopril co-treatment (p < 0.05). High levels of plasma angiotensin II (Ang II) and upregulated nicotinamide adenine dinucleotide phosphate oxidase 4 (Nox4) protein expression in the kidneys induced by l-NAME were alleviated by CT flower extract or lisinopril co-treatment (p < 0.05). Furthermore, CT flower extract and lisinopril treatment reduced lipid peroxidation and elevated plasma and kidney malondialdehyde levels in l-NAME-induced hypertensive rats (p < 0.05). In conclusion, CT flower extract prevented l-NAME-induced renal injury and dysfunction in rats. The possible mechanism may be related to the suppression of Ang II-mediated Nox4 expression and the oxidative stress cascade in rats.

据报道，Clitoria ternatia L. (CT) 具有抗炎和抗氧化作用。本研究调查了 CT 水花提取物对N ^{ω -}硝基-l -精氨酸甲酯盐酸盐 ( l -NAME) 诱导的高血压大鼠的血压和肾脏改变的影响。雄性 Sprague Dawley 大鼠在饮用水中接受l- NAME，并用 CT 花提取物或赖诺普利处理。CT 水花提取物和赖诺普利减轻了l -NAME 引起的高血压 ( p  < 0.05)。在l中观察到肾小球细胞外基质积聚、肾纤维化和血清肌酐水平升高-NAME 诱导的高血压大鼠，并通过 CT 花提取物或赖诺普利联合治疗减弱 ( p  < 0.05)。CT 花提取物或赖诺普利联合治疗可缓解由l- NAME诱导的肾脏中高水平的血浆血管紧张素 II (Ang II) 和上调的烟酰胺腺嘌呤二核苷酸磷酸氧化酶 4 (Nox4) 蛋白表达( p  < 0.05)。此外，CT 花提取物和赖诺普利处理降低了l -NAME 诱导的高血压大鼠的脂质过氧化和血浆和肾脏丙二醛水平升高( p  < 0.05)。总之，CT 花提取物防止了l-NAME 诱导的大鼠肾损伤和功能障碍。其可能的机制可能与抑制大鼠 Ang II 介导的 Nox4 表达和氧化应激级联有关。