The hydrolysate of Oncorhynchus keta (chum salmon) milt was found to exhibit strong inhibitory activity against dipeptidyl peptidase-IV (DPP-IV), and the hypoglycaemic effect of these salmon milt peptides (SMPs) was confirmed using oral starch tolerance tests in Sprague–Dawley rats. Specifically, the oral administration of SMPs at a dose of 300 mg/kg body weight for 1 week resulted in a significant decrease in the blood glucose level of the rats 60 min after starch consumption compared with the control. The bioassay-guided separation of SMPs, using a combination of column chromatographic techniques, led to the identification of 12 active di-, tri- and tetrapeptides, including four novel DPP-IV inhibitory peptides, namely Phe-Pro-Val-Gly, Leu-Pro-Val-Leu, Val-Pro-Phe-Pro and Ile-Pro-Leu. Among these 12 peptides, Ile-Pro contributed the most (1.3%) to the total DPP-IV inhibitory activity of SMPs. Therefore, SMPs may have the potential to be used as a suppressor of postprandial hyperglycaemia and to be considered a promising functional food material for the prevention of type II diabetes.

Oncorhynchus keta的水解物（鲑鱼）鱼精被发现对二肽基肽酶-IV (DPP-IV) 表现出强烈的抑制活性，并且这些鲑鱼鱼精肽 (SMP) 的降血糖作用通过 Sprague-Dawley 大鼠的口服淀粉耐受性测试得到证实。具体而言，与对照组相比，以 300 mg/kg 体重的剂量口服 SMPs 1 周导致大鼠在淀粉消耗后 60 分钟的血糖水平显着降低。SMP 的生物测定引导分离，结合柱色谱技术，鉴定了 12 种活性二肽、三肽和四肽，包括四种新型 DPP-IV 抑制肽，即 Phe-Pro-Val-Gly、Leu -Pro-Val-Leu、Val-Pro-Phe-Pro 和 Ile-Pro-Leu。在这 12 种肽中，Ile-Pro 贡献最大（1. 3%) 到 SMP 的总 DPP-IV 抑制活性。因此，SMPs 有可能被用作餐后高血糖的抑制剂，并被认为是一种有前途的预防 II 型糖尿病的功能性食品材料。