A literature review was conducted to assess the burden of serious fungal infections in the Democratic Republic of the Congo (DRC) (population 95,326,000). English and French publications were listed and analysed using PubMed/Medline, Google Scholar and the African Journals database. Publication dates spanning 1943–2020 were included in the scope of the review. From the analysis of published articles, we estimate a total of about 5,177,000 people (5.4%) suffer from serious fungal infections in the DRC annually. The incidence of cryptococcal meningitis, Pneumocystis jirovecii pneumonia in adults and invasive aspergillosis in AIDS patients was estimated at 6168, 2800 and 380 cases per year. Oral and oesophageal candidiasis represent 50,470 and 28,800 HIV-infected patients respectively. Chronic pulmonary aspergillosis post-tuberculosis incidence and prevalence was estimated to be 54,700. Fungal asthma (allergic bronchopulmonary aspergillosis and severe asthma with fungal sensitization) probably has a prevalence of 88,800 and 117,200. The estimated prevalence of recurrent vulvovaginal candidiasis and tinea capitis is 1,202,640 and 3,551,900 respectively.Further work is required to provide additional studies on opportunistic infections for improving diagnosis and the implementation of a national surveillance programme of fungal disease in the DRC.

中文翻译：

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刚果民主共和国的严重真菌病——发病率和流行率估计

进行了文献回顾以评估刚果民主共和国 (DRC)（人口 95,326,000）严重真菌感染的负担。使用 PubMed/Medline、Google Scholar 和非洲期刊数据库列出并分析了英语和法语出版物。1943-2020 年的出版日期包含在审查范围内。根据对已发表文章的分析，我们估计刚果民主共和国每年约有 5,177,000 人（5.4%）患有严重的真菌感染。隐球菌性脑膜炎、耶氏肺孢子菌的发病率据估计，成人肺炎和艾滋病患者侵袭性曲霉病每年分别为 6168、2800 和 380 例。口腔和食道念珠菌病分别代表 50,470 和 28,800 名 HIV 感染患者。结核病后慢性肺曲霉病的发病率和流行率估计为 54,700。真菌性哮喘（过敏性支气管肺曲霉病和伴有真菌致敏的严重哮喘）的患病率可能为 88,800 和 117,200。估计复发性外阴阴道念珠菌病和头癣的患病率分别为 1,202,640 和 3,551,900。需要进一步研究机会性感染，以提高诊断和实施刚果民主共和国真菌病的国家监测计划。