In recent years, the selective antibacterial properties of certain fatty acids (FA) against Staphylococcus aureus have received significant attention. In this study, the antibacterial properties of palmitoleic acid (16:1 FA) in oil (triolein), surfactant (Tween® 60), and water ternary systems were evaluated to demonstrate the effects of the mixed states on the biological activity. The 16:1 FA exhibited selective antibacterial activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 18.8 μg mL⁻¹. In contrast, palmitoleic acid did not display any activity in water-in-oil (W/O) emulsions and liquid crystal systems. In some micelle and surfactant-free oil-in-water (O/W) emulsions, the FA showed significant selective antibacterial properties against Staphylococcus aureus. These results suggested that the mixed state of the ternary mixtures affects the antibacterial behavior of FA molecules. The findings of the present study provide a valuable platform for the design of formulations of cosmetics, topical skin products, and skin cleansers.

中文翻译：

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棕榈油酸在乳液和其他配方中的选择性抗菌活性

近年来，某些脂肪酸（FA）对金黄色葡萄球菌的选择性抗菌特性受到了极大的关注。在这项研究中，评估了油（三油精）、表面活性剂（吐温® 60）和水三元系统中棕榈油酸（16:1 FA）的抗菌性能，以证明混合状态对生物活性的影响。16:1 FA 表现出对金黄色葡萄球菌的选择性抗菌活性，最低抑菌浓度 (MIC) 为 18.8 μg mL ^-1. 相比之下，棕榈油酸在油包水 (W/O) 乳液和液晶体系中没有表现出任何活性。在一些胶束和无表面活性剂的水包油 (O/W) 乳液中，FA 对金黄色葡萄球菌显示出显着的选择性抗菌特性。这些结果表明三元混合物的混合状态会影响 FA 分子的抗菌行为。本研究的结果为化妆品、外用皮肤产品和皮肤清洁剂的配方设计提供了一个有价值的平台。