Obesity is a major public health issue, and it is often associated with metabolic abnormalities. Lycium chinense Mill. polysaccharide (LCP) is considered to have antiobesity potential due to its hypoglycemic and hypolipidemic effects. However, the mechanisms associated with its antiobesity effects are still not well understood. In this study, LCP not only inhibited the size and number of lipid droplets but also led to cell death in 3T3-L1 adipocytes through downregulating cyclin D1 expression. LCP effectively decreased body weight in high-fat diet (HFD)-induced obese mice. LCP also decelerated the white adipose tissue (WAT) formation in obese mice and improved their hepatic steatosis. LCP might inhibit fatty acid synthesis and improve β-oxidation and glycolysis by modulating the gene expression of key enzymes of lipogenesis and glycolysis in adipocytes. Therefore, LCP may have antihypertrophy and antiproliferative effects and be used as a daily supplement for weight control.

中文翻译：

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枸杞多糖通过调节脂质和葡萄糖代谢抑制脂肪细胞肥大和增生

肥胖是一个主要的公共卫生问题，它通常与代谢异常有关。枸杞磨。多糖（LCP）由于其降血糖和降血脂作用被认为具有抗肥胖潜力。然而，与其抗肥胖作用相关的机制仍不清楚。在这项研究中，LCP 不仅抑制了脂滴的大小和数量，而且还通过下调细胞周期蛋白 D1 的表达导致 3T3-L1 脂肪细胞中的细胞死亡。LCP 可有效降低高脂肪饮食 (HFD) 诱导的肥胖小鼠的体重。LCP 还减缓了肥胖小鼠的白色脂肪组织 (WAT) 的形成并改善了它们的肝脏脂肪变性。LCP可能通过调节脂肪细胞中脂肪生成和糖酵解关键酶的基因表达来抑制脂肪酸合成并改善β-氧化和糖酵解。所以，