Colorectal cancer can develop through molecular, chromosomal, and epigenetic cumulative changes that transform the normal intestinal epithelium into the colorectal polyps, called conventional adenomas (CAs) or serrated polyps (SPs), recognized as precursors of invasive colorectal neoplasia. These benign lesions need to explore the morphology, histological diagnosis, and biomarkers profile to accurately characterize lesions with potential for evolution to cancer. This study aimed to correlate the immunohistochemical expression of Parkin and Adenomatous Polyposis Coli (APC; tumor suppressors), Human Apurinic/Apyrimidinic endonuclease 1 (APE1), and B-cell lymphoma-extra-large (Bcl-xL; oncogenic proteins) in sporadic colorectal polyps with clinical, endoscopic, and diagnostic data. Immunohistochemical analysis was performed on tissue microarray samples of 306 polyps. Based on the Allred score, the expressions were graduated in the cytoplasm and nucleus of superficial and cryptic cells. There was higher Parkin nuclear expression (p=0.006 and 0.010) and APC cytoplasmic expression in cryptic cells (p<0.001) in SPs. CAs, APE1 (p<0.001) and Bcl-xL (p<0.001) were more expressed in the nuclei and cytoplasms, respectively. These results are related to the biological role proposed for these proteins in cellular functions. They can contribute to the diagnosis criteria for polyps and improve the knowledge of biomarkers that could predict cancer development:

结直肠癌可以通过分子、染色体和表观遗传累积变化发展，这些变化将正常肠上皮转化为结直肠息肉，称为常规腺瘤 (CA) 或锯齿状息肉 (SP)，被认为是侵袭性结直肠肿瘤的前兆。这些良性病变需要探索形态学、组织学诊断和生物标志物特征，以准确表征有可能演变为癌症的病变。本研究旨在将 Parkin 和腺瘤性息肉病大肠杆菌（APC；肿瘤抑制因子）、人无嘌呤/无嘧啶核酸内切酶 1（APE1）和 B 细胞淋巴瘤超大（Bcl-xL；致癌蛋白）在散发性具有临床、内窥镜和诊断数据的结直肠息肉。对 306 个息肉的组织微阵列样本进行了免疫组织化学分析。基于Allred评分，表达在表层和隐蔽细胞的细胞质和细胞核中分级。有更高的 Parkin 核表达（p = 0.006 和 0.010) 以及SP中隐匿细胞中的 APC 细胞质表达 ( p <0.001)。CA、APE1 ( p <0.001) 和 Bcl-xL ( p <0.001) 分别在细胞核和细胞质中表达更多。这些结果与这些蛋白质在细胞功能中的生物学作用有关。它们可以为息肉的诊断标准做出贡献，并提高对可以预测癌症发展的生物标志物的了解：