Kidney outcomes using a sustained ≥40% decline in eGFR: A meta-analysis of SGLT2 inhibitor trials,Clinical Cardiology

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Kidney outcomes using a sustained ≥40% decline in eGFR: A meta-analysis of SGLT2 inhibitor trials
Clinical Cardiology ( IF 2.4 ) Pub Date : 2021-06-15 , DOI: 10.1002/clc.23665
David Z I Cherney ₁ , Samuel Dagogo-Jack ₂ , Darren K McGuire ₃ , Francesco Cosentino ₄ , Richard Pratley ₅ , Weichung J Shih ₆ , Robert Frederich ₇ , Mario Maldonado ₈ , Jie Liu ₉ , Shuai Wang ₁₀ , Christopher P Cannon ₁₁ ,

Affiliation

Division of Nephrology, University of Toronto, Toronto, Ontario, Canada.
Division of Endocrinology, Diabetes and Metabolism, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Division of Cardiology, University of Texas Southwestern Medical Center, and Parkland Health and Hospital System, Dallas, Texas, USA.
Unit of Cardiology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden.
AdventHealth Translational Research Institute, Orlando, Florida, USA.
Department of Biostatistics and Epidemiology, Rutgers School of Public Health and Rutgers Cancer Institute of New Jersey, New Brunswick, New Jersey, USA.
Clinical Development and Operations, Research and Development, Pfizer Inc., Collegeville, Pennsylvania, USA.
Diabetes and Endocrinology, MSD Limited, London, UK.
Global Product Development Statistics, Merck & Co., Inc., Kenilworth, New Jersey, USA.
Pfizer Inc., Groton, Connecticut, USA.
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

A recent meta-analysis of sodium–glucose cotransporter 2 (SGLT2) inhibitor outcome trials reported that SGLT2 inhibitors were associated with reduction in the risk of adverse composite kidney outcomes, with moderate heterogeneity across the trials; however, the endpoints were defined differently across the trials.

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