ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis,Clinical & Experimental Allergy

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ADRB2 haplotypes and asthma exacerbations in children and young adults: An individual participant data meta-analysis
Clinical & Experimental Allergy ( IF 6.1 ) Pub Date : 2021-06-15 , DOI: 10.1111/cea.13965
Leila Karimi ₁ , Susanne J Vijverberg _{2,

3,

4} , Marjolein Engelkes ₁ , Natalia Hernandez-Pacheco _{5,

6} , Niloufar Farzan _{2,

4} , Patricia Soares ₇ , Maria Pino-Yanes _{6,

8,

9} , Andrea L Jorgensen ₁₀ , Celeste Eng ₁₁ , Somnath Mukhopadhyay ₇ , Maximilian Schieck _{12,

13} , Michael Kabesch ₁₂ , Esteban G Burchard _{11,

14} , Fook Tim Chew ₁₅ , Yang Yie Sio ₁₅ , Uroš Potočnik _{16,

17} , Mario Gorenjak ₁₆ , Daniel B Hawcutt _{18,

19} , Colin N Palmer ₂₀ , Steve Turner ₂₁ , Hettie M Janssens ₂₂ , Anke H Maitland-van der Zee _{2,

3,

4} , Katia M C Verhamme _{1,

23} ,

Affiliation

Department of Medical Informatics, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Respiratory Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Department of Pediatric Respiratory Medicine and Allergy, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.
Division of Pharmacoepidemiology and Clinical Pharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS), Faculty of Science, Utrecht University, Utrecht, The Netherlands.
Research Unit, Hospital Universitario N.S. de Candelaria, Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Genomics and Health Group, Department of Biochemistry, Microbiology, Cell Biology and Genetics, Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
Academic Department of Pediatrics, Brighton & Sussex Medical School, Royal Alexandra Children's Hospital, Brighton, UK.
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain.
Instituto de Tecnologías Biomédicas (ITB), Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK.
Department of Medicine, University of California, San Francisco, CA, USA.
Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO, Regensburg, Germany.
Department of Human Genetics, Hannover Medical School, Hannover, Germany.
Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA, USA.
Department of Biological Sciences, National University of Singapore, Singapore, Singapore.
Center for Human Molecular Genetics and Pharmacogenomics, Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Laboratory for Biochemistry, Molecular Biology and Genomics, Faculty of Chemistry and Chemical Engineering, University of Maribor, Maribor, Slovenia.
Members of Liverpool Health Partners, University of Liverpool and Alder Hey Children's Hospital, Liverpool, UK.
NIHR Alder Hey Clinical Research Facility, Alder Hey Children's Hospital, Liverpool, UK.
Division of Cardiovascular and Diabetes Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
Child Health, University of Aberdeen, Aberdeen, UK.
Department of Pediatrics/division Respiratory Medicine and Allergology Erasmus MC/Sophia Children's Hospital, Erasmus University Medical Center, Rotterdam, The Netherlands.
Department of Bioanalysis, Ghent University, Ghent, Belgium.

The polymorphism Arg16 in β₂-adrenergic receptor (ADRB2) gene has been associated with an increased risk of exacerbations in asthmatic children treated with long-acting β₂-agonists (LABA). However, it remains unclear whether this increased risk is mainly attributed to this single variant or the combined effect of the haplotypes of polymorphisms at codons 16 and 27.

中文翻译：

儿童和年轻人的 ADRB2 单倍型和哮喘发作：个体参与者数据荟萃分析

_{β 2} - 肾上腺素能受体 ( ADRB2 ) 基因中的多态性 Arg16与使用长效 β ₂ -激动剂 (LABA) 治疗的哮喘儿童恶化风险增加有关。然而，尚不清楚这种增加的风险是否主要归因于这种单一变体或密码子 16 和 27 的多态性单倍型的组合效应。

更新日期：2021-06-15

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