The nuclear pore complex (NPC) is a highly conserved channel in the nuclear envelope that mediates mRNA export to the cytosol and bidirectional protein transport. Many chromosomal loci physically interact with nuclear pore proteins (Nups), and interactions with Nups can promote transcriptional repression, transcriptional activation, and transcriptional poising. Interaction with the NPC also affects the spatial arrangement of genes, interchromosomal clustering, and folding of topologically associated domains. Thus, the NPC is a spatial organizer of the genome and regulator of genome function.

中文翻译：

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核孔复合体作为转录调节剂

核孔复合物 (NPC) 是核膜中一个高度保守的通道，它介导 mRNA 输出到胞质溶胶和双向蛋白质转运。许多染色体基因座与核孔蛋白 (Nups) 发生物理相互作用，并且与 Nups 的相互作用可以促进转录抑制、转录激活和转录平衡。与 NPC 的相互作用也会影响基因的空间排列、染色体间的聚类和拓扑相关域的折叠。因此，NPC 是基因组的空间组织者和基因组功能的调节剂。