Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer’s disease,Annals of Clinical and Translational Neurology

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Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer’s disease
Annals of Clinical and Translational Neurology ( IF 4.4 ) Pub Date : 2021-06-15 , DOI: 10.1002/acn3.51402
Sofia Bergström ₁ , Julia Remnestål ₁ , Jamil Yousef ₁ , Jennie Olofsson ₁ , Ioanna Markaki ₂ , Stephanie Carvalho ₃ , Jean-Christophe Corvol ₃ , Kim Kultima ₄ , Lena Kilander ₅ , Malin Löwenmark ₅ , Martin Ingelsson ₅ , Kaj Blennow _{6,

7} , Henrik Zetterberg _{6,

7,

8,

9} , Bengt Nellgård _{10,

11} , Frederic Brosseron _{12,

13} , Michael T Heneka ₁₂ , Beatriz Bosch ₁₄ , Raquel Sanchez-Valle ₁₄ , Anna Månberg ₁ , Per Svenningsson ₂ , Peter Nilsson ₁

Affiliation

Division of Affinity Proteomics, Department of Protein Science, SciLifeLab, KTH Royal Institute of Technology, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Sorbonne Université, Institut du Cerveau - Paris Brain Institute - ICM, Assistance-Publique Hôpitaux de Paris, INSERM, CNRS, Hôpital Pitié-Salpêtrière, Department of Neurology, Centre d'Investigation Clinique Neurosciences, Paris, France.
Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Department of Public Health and Caring Sciences, Geriatrics, Uppsala University, Uppsala, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy, University of Gothenburg.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
UK Dementia Research Institute at UCL, London, UK.
Anesthesiology and Intensive Care Medicine, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Anesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg.
Universitätsklinikum Bonn, Germany.
German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
Alzheimer's and other cognitive disorders Unit. Service of Neurology, Hospital Clínic de Barcelona, Institut d'Investigació Biomèdica August Pi i Sunyer, University of Barcelona, Barcelona, Spain.

Decreased amyloid beta (Aβ) 42 together with increased tau and phospho-tau in cerebrospinal fluid (CSF) is indicative of Alzheimer’s disease (AD). However, the molecular pathophysiology underlying the slowly progressive cognitive decline observed in AD is not fully understood and it is not known what other CSF biomarkers may be altered in early disease stages.

中文翻译：

多队列分析显示阿尔茨海默病中脑富集蛋白的脑脊液水平升高

脑脊液 (CSF) 中β-淀粉样蛋白 (Aβ) 42 的降低以及 tau 和磷酸化 tau 的增加表明阿尔茨海默病 (AD)。然而，在 AD 中观察到的缓慢进行性认知衰退背后的分子病理生理学尚不完全清楚，也不知道在疾病早期阶段可能会改变哪些其他 CSF 生物标志物。

更新日期：2021-07-16

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