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Targeting the adipose tissue to protect the heart
Nature Reviews Cardiology ( IF 49.6 ) Pub Date : 2021-06-15 , DOI: 10.1038/s41569-021-00588-3
Irene Fernández-Ruiz 1
Affiliation  

Treatment with atglistatin, an inhibitor of adipose triglyceride lipase (ATGL) activity, has cardioprotective effects against catecholamine-induced cardiac damage in mice, according to a new study. Atglistatin inhibited adipose ATGL activity but had no effect on cardiac ATGL, indicating that its cardioprotective effects are mediated by non-cardiac actions.

中文翻译:

针对脂肪组织保护心脏

根据一项新的研究,用阿格列他汀(一种脂肪甘油三酯脂肪酶 (ATGL) 活性抑制剂)治疗对儿茶酚胺引起的小鼠心脏损伤具有心脏保护作用。Atglistatin 抑制脂肪 ATGL 活性,但对心脏 ATGL 没有影响,表明其心脏保护作用是由非心脏作用介导的。
更新日期:2021-06-15
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